HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: NUF2 (Q9BZD4)
Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1)
Gene: NUF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 26496610, 24981860, 33961781, 35271311, 31839598, 14602875, 14699129, 34079125, 36883282, 35235311, 37071682, 20360068, 25416956, 15961401, unassigned3799, 17129783
Identification Methods affinity chromatography technology, cross-linking study, two hybrid, proximity labelling technology, x-ray crystallography, mammalian protein protein interaction trap, anti tag coimmunoprecipitation, pull down, molecular sieving, anti bait coimmunoprecipitation and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF5595~Nuf2, Ndc80_HEC~Nuf2
Common GO terms GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007052 - mitotic spindle organization
and 9 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 642
Hs

1 464
+ Hs
+ Gg
+ Xl
+ Hs
+ Hs
+ Sp
+ Hs
+ Rn
+ Rn
+ Hs
+ Rn
+ Ce
+ Hs
+ Sc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 11Aug2025