HitPredict

Interactor 1: TIF1A (O15164)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: TRIM24

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29129908
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression and 1 others more... GO:0043434 - response to peptide hormone
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1050 Hs			1 770
+	Hs
		776822 TRI45_HUMAN (44-411): 2.3e-68: 242: 23.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776769 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776739 TRI22_HUMAN (122-481): 1.35e-62: 223: 12.12		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		668483 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		170290 TIF1A_HUMAN (1-1050): 0: 590: 100.00		STAT6_HUMAN (1-753): 0: 627: 24.10
+	Hs
		776670 TIF1B_HUMAN (698-1033): 1.83e-29: 128: 22.06		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		786400 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		584894 RO52_HUMAN (114-485): 2.09e-64: 227: 12.67		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		668490 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		786334 TIF1B_HUMAN (698-1033): 1.83e-29: 128: 22.06		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		1029430 TIF1B_HUMAN (698-1033): 1.83e-29: 128: 22.06		STAT4_HUMAN (1-729): 0: 893: 48.44
+	Hs
		855311 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Hs
		668536 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Hs
		849905 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		786628 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Mm
		70905 EP300_MOUSE (376-1001): 3.38e-64: 240: 15.94		STAT6_MOUSE (1-761): 0: 668: 25.69
+	Hs
		786494 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		STAT6_HUMAN (1-753): 0: 627: 24.10
+	Hs
		786479 TIF1B_HUMAN (698-1033): 1.83e-29: 128: 22.06		STAT6_HUMAN (1-753): 0: 627: 24.10
+	Mm
		1143658 RO52_MOUSE (110-485): 2.45e-62: 221: 13.84		Q8CFQ1_MOUSE (524-749): 2.28e-98: 306: 46.78