Protein: U17L2
Ubiquitin carboxyl-terminal hydrolase 17 (USP17) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2)

Gene: U17L2, USP17L2
Organism: Homo sapiens
Interactions: 31
UniProt ID: Q6R6M4

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350050

SNAI1
Zinc finger protein SNAI1

4

8

Small-scale

0.708

High

505394

U17L7
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7

1

13

High-throughput

0.691

High

508156

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

1060270

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

3

1

Small-scale

0.640

High

1121426

KEAP1
Kelch-like ECH-associated protein 1

2

8

Small-scale

0.584

High

549181

CDK4
Cyclin-dependent kinase 4

1

9

Small-scale

0.578

High

1025371

CDK6
Cyclin-dependent kinase 6

1

9

Small-scale

0.578

High

1247084

KMT5A
N-lysine methyltransferase KMT5A

1

8

Small-scale

0.578

High

1082528

U17LO
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

1

13

High-throughput

0.575

High

216956

KLF4
Krueppel-like factor 4

1

12

Small-scale

0.561

High

260099

BRD4
Bromodomain-containing protein 4

1

15

Small-scale

0.561

High

591694

H2AX
Histone H2AX

1

15

Small-scale

0.561

High

622464

ELK1
ETS domain-containing protein Elk-1

1

5

Small-scale

0.561

High

1247085

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

Small-scale

0.561

High

1247083

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

Small-scale

0.537

High

1014134

CBX1
Chromobox protein homolog 1

1

7

High-throughput

0.536

High

1029317

SET
Protein SET

1

10

High-throughput

0.536

High

1247082

LGMN
Legumain

1

1

Small-scale

0.512

High

170203

AURKA
Aurora kinase A

1

6

Small-scale

0.479

High

221801

SNAI2
Zinc finger protein SNAI2

1

7

Small-scale

0.479

High

629133

CCNA2
Cyclin-A2

1

2

Small-scale

0.479

High

719341

MPIP3
M-phase inducer phosphatase 3

1

1

Small-scale

0.479

High

764841

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

1090727

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1094913

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1151960

TWST1
Twist-related protein 1

1

6

Small-scale

0.479

High

1156667

NF2L2
Nuclear factor erythroid 2-related factor 2

1

10

Small-scale

0.479

High

1247081

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.479

High

344443

IL33
Interleukin-33

1

0

Small-scale

0.458

High

1231727

NXN
Nucleoredoxin

1

0

Small-scale

0.458

High

293880

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High


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Last updated: 11Aug2025