Protein: UBP40
Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40)

Gene: UBP40, USP40
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q9NVE5

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0016579 - protein deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508707

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

High-throughput

0.778

High

992992

RACK1
Small ribosomal subunit protein RACK1

1

11

Small-scale

0.621

High

996362

EF1A1
Elongation factor 1-alpha 1

1

6

Small-scale

0.621

High

890225

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

1

Small-scale

0.552

High

421203

ALDOB
Fructose-bisphosphate aldolase B

1

3

Small-scale

0.481

High

451081

LDHB
L-lactate dehydrogenase B chain

1

4

Small-scale

0.481

High

537988

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.481

High

548872

ADHX
Alcohol dehydrogenase class-3

1

1

Small-scale

0.481

High

567496

TCTP
Translationally-controlled tumor protein

1

2

Small-scale

0.481

High

714979

EF1D
Elongation factor 1-delta

1

2

Small-scale

0.481

High

954288

RS20
Small ribosomal subunit protein uS10

1

1

Small-scale

0.481

High

959992

RS3A
Small ribosomal subunit protein eS1

1

1

Small-scale

0.481

High

972975

RS18
Small ribosomal subunit protein uS13

1

2

Small-scale

0.481

High

984560

RL30
Large ribosomal subunit protein eL30

1

2

Small-scale

0.481

High

1029563

SRSF2
Serine/arginine-rich splicing factor 2

1

6

Small-scale

0.481

High

1410193

TCF25
Ribosome quality control complex subunit TCF25

1

2

Small-scale

0.481

High

1433641

E41L1
Band 4.1-like protein 1

1

7

Small-scale

0.481

High

1450409

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.481

High

1450411

RBX2
RING-box protein 2

1

1

Small-scale

0.481

High

170380

AURKA
Aurora kinase A

1

10

Small-scale

0.479

High

193050

CFLAR
CASP8 and FADD-like apoptosis regulator

1

3

Small-scale

0.479

High

1135128

CUL7
Cullin-7

1

1

High-throughput

0.479

High

1450413

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

337034

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.460

High

391716

MT2
Metallothionein-2

1

0

Small-scale

0.460

High

1278364

COMD6
COMM domain-containing protein 6

1

0

Small-scale

0.460

High

1450414

TPPC8
Trafficking protein particle complex subunit 8

1

0

Small-scale

0.460

High

1450416

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

Small-scale

0.458

High

369759

A2MG
Alpha-2-macroglobulin

1

3

Small-scale

0.439

High

388670

C1QA
Complement C1q subcomponent subunit A

1

3

Small-scale

0.439

High

652259

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

Small-scale

0.439

High

1022655

LRP2
Low-density lipoprotein receptor-related protein 2

1

1

Small-scale

0.439

High

1115505

S12A1
Solute carrier family 12 member 1

1

3

Small-scale

0.439

High

1128891

I11RA
Interleukin-11 receptor subunit alpha

1

5

Small-scale

0.439

High

1386087

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

5

Small-scale

0.439

High

1450415

HEBP2
Heme-binding protein 2

1

1

Small-scale

0.439

High

1450410

RRBP1
Ribosome-binding protein 1

1

11

High-throughput

0.437

High

337195

APOM
Apolipoprotein M

1

0

Small-scale

0.251

Low

510022

HMN1
Humanin-like 1

1

0

Small-scale

0.251

Low

655020

ITA6
Integrin alpha-6

1

0

Small-scale

0.251

Low

863566

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

Small-scale

0.251

Low

1105573

OS9
Protein OS-9

1

0

Small-scale

0.251

Low

1147693

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.251

Low

1159868

OCLN
Occludin

1

0

Small-scale

0.251

Low

1308413

PSTK
L-seryl-tRNA(Sec) kinase

1

0

Small-scale

0.251

Low

1450412

CLN8
Protein CLN8

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025