Protein: USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y (EC 3.4.19.12) (Deubiquitinating enzyme FAF-Y) (Fat facets protein-related, Y-linked) (Ubiquitin thioesterase FAF-Y) (Ubiquitin-specific protease 9, Y chromosome) (Ubiquitin-specific-processing protease FAF-Y)

Gene: USP9Y
Organism: Homo sapiens
Interactions: 50
UniProt ID: O00507

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138917

CLK3
Dual specificity protein kinase CLK3

2

12

High-throughput

0.628

High

138943

ZN331
Zinc finger protein 331

2

2

High-throughput

0.628

High

138902

PRKN
E3 ubiquitin-protein ligase parkin

1

19

High-throughput

0.618

High

138935

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

15

High-throughput

0.618

High

138944

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.602

High

138920

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.601

High

138914

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

11

High-throughput

0.571

High

138926

KPCD1
Serine/threonine-protein kinase D1

2

6

High-throughput

0.571

High

138933

RSPH1
Radial spoke head 1 homolog

1

2

High-throughput

0.541

High

138901

SOCS1
Suppressor of cytokine signaling 1

1

6

High-throughput

0.536

High

138908

SHC1
SHC-transforming protein 1

1

10

High-throughput

0.536

High

138909

AKT2
RAC-beta serine/threonine-protein kinase

1

10

High-throughput

0.536

High

138916

KC1E
Casein kinase I isoform epsilon

1

5

High-throughput

0.536

High

138931

DDHD1
Phospholipase DDHD1

1

1

High-throughput

0.536

High

138938

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.536

High

138905

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.527

High

138936

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

13

Small-scale

0.515

High

138937

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

138940

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.513

High

138900

CCL16
C-C motif chemokine 16

1

2

High-throughput

0.489

High

138910

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.489

High

138927

K0408
Uncharacterized protein KIAA0408

1

1

High-throughput

0.489

High

138903

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

138904

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.479

High

138907

IF4B
Eukaryotic translation initiation factor 4B

1

12

Small-scale

0.479

High

138911

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

138912

ZEB1
Zinc finger E-box-binding homeobox 1

1

10

Small-scale

0.479

High

138913

MATR3
Matrin-3

1

8

High-throughput

0.479

High

138918

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

138921

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

14

High-throughput

0.479

High

138922

TAGL
Transgelin

1

8

Small-scale

0.479

High

138923

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

138925

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

138932

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

138934

ARHG2
Rho guanine nucleotide exchange factor 2

1

4

High-throughput

0.479

High

138941

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

138942

ECT2
Protein ECT2

1

6

High-throughput

0.479

High

138945

VSX1
Visual system homeobox 1

1

8

High-throughput

0.479

High

138947

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

138915

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

138919

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.458

High

138929

AF1L2
Actin filament-associated protein 1-like 2

1

0

High-throughput

0.458

High

138906

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

138924

ABRX2
BRISC complex subunit Abraxas 2

1

1

Small-scale

0.445

High

138928

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

138939

DCR1C
Protein artemis

1

0

High-throughput

0.279

Low

138946

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.279

Low

138948

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

67439

CFA96
Cilia-and flagella-associated protein 96

1

0

High-throughput

0.269

Low

138930

TMM75
Putative protein encoded by LINC02912

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025