Protein: DRB1
HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)

Gene: DRB1, HLA-DRB1
Organism: Homo sapiens
Interactions: 112
UniProt ID: P01911

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001772 - immunological synapse
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0001934 - positive regulation of protein phosphorylation
GO:0002437 - inflammatory response to antigenic stimulus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

380238

DRA
HLA class II histocompatibility antigen, DR alpha chain

3

18

Small-scale

0.834

High

380562

RN149
E3 ubiquitin-protein ligase RNF149

2

12

High-throughput

0.712

High

249371

MPZL2
Myelin protein zero-like protein 2

1

12

High-throughput

0.575

High

380509

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

18

High-throughput

0.575

High

380510

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

18

High-throughput

0.575

High

380511

HG2A
HLA class II histocompatibility antigen gamma chain

1

8

High-throughput

0.575

High

380512

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

19

High-throughput

0.575

High

380513

CD1A
T-cell surface glycoprotein CD1a

1

20

High-throughput

0.575

High

380516

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

20

High-throughput

0.575

High

380518

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

20

High-throughput

0.575

High

380520

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

20

High-throughput

0.575

High

380523

DMA
HLA class II histocompatibility antigen, DM alpha chain

1

19

Small-scale

0.575

High

380524

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

20

High-throughput

0.575

High

380532

IDD
Integral membrane protein DGCR2/IDD

1

5

High-throughput

0.575

High

380548

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

1

20

High-throughput

0.575

High

380563

CADM4
Cell adhesion molecule 4

1

5

High-throughput

0.575

High

380566

NEUFC
Neuferricin

1

3

High-throughput

0.575

High

380567

BT2A2
Butyrophilin subfamily 2 member A2

1

10

High-throughput

0.575

High

380571

HMR1
Major histocompatibility complex class I-related protein 1

1

20

High-throughput

0.575

High

380586

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.575

High

380594

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

2

High-throughput

0.575

High

380599

BTNL2
Butyrophilin-like protein 2

1

14

High-throughput

0.575

High

380601

CLC4E
C-type lectin domain family 4 member E

1

7

High-throughput

0.575

High

380540

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

2

1

High-throughput

0.552

High

380595

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

2

7

High-throughput

0.552

High

380515

HS71A
Heat shock 70 kDa protein 1A

1

7

Small-scale

0.501

High

61075

T131L
Transmembrane protein 131-like

1

6

High-throughput

0.445

High

170469

RAB7L
Ras-related protein Rab-7L1

1

9

High-throughput

0.445

High

178137

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.445

High

194798

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

1

High-throughput

0.445

High

209367

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

11

High-throughput

0.445

High

341271

ECEL1
Endothelin-converting enzyme-like 1

1

9

High-throughput

0.445

High

343832

SEM4F
Semaphorin-4F

1

11

High-throughput

0.445

High

380514

NEP
Neprilysin

1

9

Small-scale

0.445

High

380517

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

3

High-throughput

0.445

High

380519

PERF
Perforin-1

1

1

High-throughput

0.445

High

380521

CD9
CD9 antigen

1

9

Small-scale

0.445

High

380522

ITA6
Integrin alpha-6

1

4

High-throughput

0.445

High

380525

SCNNA
Epithelial sodium channel subunit alpha

1

12

High-throughput

0.445

High

380527

AT12A
Potassium-transporting ATPase alpha chain 2

1

11

High-throughput

0.445

High

380534

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

16

High-throughput

0.445

High

380535

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

5

High-throughput

0.445

High

380536

NUCB1
Nucleobindin-1

1

2

High-throughput

0.445

High

380538

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.445

High

380539

SLC31
Amino acid transporter heavy chain SLC3A1

1

4

High-throughput

0.445

High

380541

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

9

High-throughput

0.445

High

380543

STAR3
StAR-related lipid transfer protein 3

1

2

High-throughput

0.445

High

380544

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.445

High

380545

PON2
Serum paraoxonase/arylesterase 2

1

3

High-throughput

0.445

High

380547

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

5

High-throughput

0.445

High

380549

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.445

High

380550

GXLT1
Glucoside xylosyltransferase 1

1

5

High-throughput

0.445

High

380553

TGO1
Transport and Golgi organization protein 1 homolog

1

2

High-throughput

0.445

High

380556

TBA1A
Tubulin alpha-1A chain

1

7

High-throughput

0.445

High

380558

GALT5
Polypeptide N-acetylgalactosaminyltransferase 5

1

11

High-throughput

0.445

High

380561

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.445

High

380564

TIP
T-cell immunomodulatory protein

1

3

High-throughput

0.445

High

380565

SCRB1
Scavenger receptor class B member 1

1

3

High-throughput

0.445

High

380568

ELYS
Protein ELYS

1

2

High-throughput

0.445

High

380569

TM131
Transmembrane protein 131

1

8

High-throughput

0.445

High

380570

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

10

High-throughput

0.445

High

380572

T106A
Transmembrane protein 106A

1

15

High-throughput

0.445

High

380574

ASIC4
Acid-sensing ion channel 4

1

12

High-throughput

0.445

High

380579

CSTN3
Calsyntenin-3

1

7

High-throughput

0.445

High

380582

TMM59
Transmembrane protein 59

1

2

High-throughput

0.445

High

380583

ABCA2
ATP-binding cassette sub-family A member 2

1

5

High-throughput

0.445

High

380584

ADT4
ADP/ATP translocase 4

1

11

High-throughput

0.445

High

380587

CHST8
Carbohydrate sulfotransferase 8

1

8

High-throughput

0.445

High

380591

CNNM1
Metal transporter CNNM1

1

8

High-throughput

0.445

High

380592

T106B
Transmembrane protein 106B

1

15

High-throughput

0.445

High

380593

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

1

High-throughput

0.445

High

380597

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

4

High-throughput

0.445

High

380600

S39AA
Zinc transporter ZIP10

1

12

High-throughput

0.445

High

380602

AT1B4
Protein ATP1B4

1

6

High-throughput

0.445

High

380603

S22AE
Solute carrier family 22 member 14

1

3

High-throughput

0.445

High

380604

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

8

High-throughput

0.445

High

380533

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.438

High

212531

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.426

High

248428

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

0

High-throughput

0.426

High

380530

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

0

High-throughput

0.426

High

380537

P
P protein

1

0

High-throughput

0.426

High

380542

ERG1
Squalene monooxygenase

1

0

High-throughput

0.426

High

380557

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.426

High

380559

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.426

High

380560

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.426

High

380577

PIGS
GPI-anchor transamidase component PIGS

1

0

High-throughput

0.426

High

380578

RNF5
E3 ubiquitin-protein ligase RNF5

1

0

High-throughput

0.426

High

380580

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.426

High

328345

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

1

High-throughput

0.407

High

337930

CNEP1
CTD nuclear envelope phosphatase 1

1

1

High-throughput

0.407

High

380526

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

2

High-throughput

0.407

High

380531

SSBP2
Single-stranded DNA-binding protein 2

1

3

High-throughput

0.407

High

380546

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

High-throughput

0.407

High

380551

MPPE1
Metallophosphoesterase 1

1

1

High-throughput

0.407

High

380552

MKS3
Meckelin

1

4

High-throughput

0.407

High

380554

TM201
Transmembrane protein 201

1

2

High-throughput

0.407

High

380555

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

380573

SARAF
Store-operated calcium entry-associated regulatory factor

1

5

High-throughput

0.407

High

380575

TECT2
Tectonic-2

1

6

High-throughput

0.407

High

380576

P121A
Nuclear envelope pore membrane protein POM 121

1

4

High-throughput

0.407

High

380581

T106C
Transmembrane protein 106C

1

15

High-throughput

0.407

High

380585

RAB6C
Ras-related protein Rab-6C

1

6

High-throughput

0.407

High

380588

UD17
UDP-glucuronosyltransferase 1A7

1

6

High-throughput

0.407

High

380589

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.407

High

380596

EXTL2
Exostosin-like 2

1

6

High-throughput

0.407

High

380598

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

1

High-throughput

0.407

High

380590

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

223785

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.232

Low

328285

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

High-throughput

0.232

Low

380528

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.232

Low

380529

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025