HitPredict

Interactor 1: EIF3H (O15372)
Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)
Gene: EIF3H

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003743 - translation initiation factor activity GO:0005829 - cytosol GO:0006413 - translational initiation GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 352 Hs			1 406
+	Hs
		177022 EIF3H_HUMAN (1-352): 6.57e-120: 351: 100.00		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		124860 EIF3F_HUMAN (13-334): 2.26e-72: 230: 17.39		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Sc
		485758 RPN11_YEAST (16-285): 1.36e-61: 201: 22.41		IF4A_YEAST (20-406): 8.01e-168: 477: 66.41
+	Hs
		124753 EIF3F_HUMAN (13-334): 2.26e-72: 230: 17.39		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		1271613 CSN5_HUMAN (16-310): 1.83e-72: 230: 17.26		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		571540 CSN5_HUMAN (16-310): 1.83e-72: 230: 17.26		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		176950 EIF3H_HUMAN (1-352): 6.57e-120: 351: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		130730 PSDE_HUMAN (28-290): 2.44e-66: 213: 21.75		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		131026 PSDE_HUMAN (28-290): 2.44e-66: 213: 21.75		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		124815 EIF3F_HUMAN (13-334): 2.26e-72: 230: 17.39		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		571502 CSN6_HUMAN (8-334): 4.21e-64: 208: 15.27		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		892868 CSN5_HUMAN (16-310): 1.83e-72: 230: 17.26		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Sc
		624119 RPN11_YEAST (16-285): 1.36e-61: 201: 22.41		DBP2_YEAST (2-404): 8.49e-137: 403: 31.63
+	Hs
		640573 CSN5_HUMAN (16-310): 1.83e-72: 230: 17.26		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Sc
		761970 RPN11_YEAST (16-285): 1.36e-61: 201: 22.41		DHH1_YEAST (32-402): 1.41e-99: 307: 44.47