Protein: PTPR2
Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]

Gene: PTPR2, PTPRN2
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q92932

Gene Ontology (top 5):
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0006470 - protein dephosphorylation
GO:0006629 - lipid metabolic process
GO:0007269 - neurotransmitter secretion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1164065

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

2

19

High-throughput

0.811

High

522714

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

18

High-throughput

0.691

High

541623

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.691

High

557416

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.691

High

1340217

MSPD2
Motile sperm domain-containing protein 2

2

5

High-throughput

0.628

High

987824

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

404292

GCR
Glucocorticoid receptor

2

6

High-throughput

0.584

High

1370797

TELO2
Telomere length regulation protein TEL2 homolog

2

1

High-throughput

0.558

High

1370787

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

18

Small-scale

0.545

High

163340

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

9

High-throughput

0.536

High

297115

PAK3
Serine/threonine-protein kinase PAK 3

1

6

High-throughput

0.536

High

890028

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

1370791

SORT
Sortilin

1

0

High-throughput

0.513

High

1370792

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

1119865

CKAP5
Cytoskeleton-associated protein 5

1

11

Small-scale

0.508

High

1370794

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

4

Small-scale

0.508

High

207711

SGSM2
Small G protein signaling modulator 2

1

4

High-throughput

0.489

High

963112

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

6

High-throughput

0.489

High

1022761

XIAP
E3 ubiquitin-protein ligase XIAP

1

2

High-throughput

0.489

High

1107442

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

High-throughput

0.489

High

1277511

MON2
Protein MON2 homolog

1

4

High-throughput

0.489

High

535375

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.479

High

627385

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

6

High-throughput

0.479

High

1105646

GOGA4
Golgin subfamily A member 4

1

2

High-throughput

0.479

High

1370793

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1370795

UBQL4
Ubiquilin-4

1

6

High-throughput

0.464

High

1111639

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1119239

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

169683

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.437

High

220959

XPOT
Exportin-T

1

20

High-throughput

0.437

High

291471

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

296542

STAM2
Signal transducing adapter molecule 2

1

10

High-throughput

0.437

High

359705

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.437

High

385151

K1C14
Keratin, type I cytoskeletal 14

1

3

High-throughput

0.437

High

476368

K1C16
Keratin, type I cytoskeletal 16

1

3

High-throughput

0.437

High

613123

EGR1
Early growth response protein 1

1

4

High-throughput

0.437

High

651848

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.437

High

841852

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.437

High

1047465

K1C17
Keratin, type I cytoskeletal 17

1

3

High-throughput

0.437

High

1220710

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.437

High

1242081

TTC27
Tetratricopeptide repeat protein 27

1

3

High-throughput

0.437

High

1310768

CUL9
Cullin-9

1

2

High-throughput

0.437

High

1325506

FBXW8
F-box/WD repeat-containing protein 8

1

3

High-throughput

0.437

High

1364077

SNX19
Sorting nexin-19

1

1

High-throughput

0.437

High

1365718

GCN1
Stalled ribosome sensor GCN1

1

16

High-throughput

0.437

High

1365874

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.437

High

1368281

STAM1
Signal transducing adapter molecule 1

1

10

High-throughput

0.437

High

1370788

TNPO1
Transportin-1

1

16

High-throughput

0.437

High

1370790

CLCC1
Chloride channel CLIC-like protein 1

1

1

High-throughput

0.437

High

1370796

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.437

High

1312568

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

Small-scale

0.407

High

773947

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

1215000

INT11
Integrator complex subunit 11

1

0

High-throughput

0.279

Low

1370789

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

994940

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.249

Low

1136146

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.249

Low

1210359

NU188
Nucleoporin NUP188

1

0

High-throughput

0.249

Low

1293969

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.249

Low

1308384

HID1
Protein HID1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025