Protein: PTPRR
Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)

Gene: PTPRR
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q15256

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1144522

PTPRR
Receptor-type tyrosine-protein phosphatase R

3

18

Small-scale

0.812

High

411971

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.793

High

703601

MK01
Mitogen-activated protein kinase 1

10

20

Small-scale

0.758

High

410857

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.752

High

439740

INSR
Insulin receptor

1

20

High-throughput

0.752

High

1144526

MK14
Mitogen-activated protein kinase 14

7

20

Small-scale

0.751

High

363313

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.698

High

463969

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.698

High

465526

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.698

High

641177

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.698

High

641601

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.698

High

648516

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.698

High

710250

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.698

High

761226

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.698

High

778069

VGFR2
Vascular endothelial growth factor receptor 2

1

20

High-throughput

0.698

High

1034158

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.698

High

1034236

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.698

High

1038436

TIE2
Angiopoietin-1 receptor

1

20

High-throughput

0.698

High

1101727

PTK7
Inactive tyrosine-protein kinase 7

1

20

High-throughput

0.698

High

1144523

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.698

High

1144531

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.698

High

1144533

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.698

High

691747

MK03
Mitogen-activated protein kinase 3

3

20

Small-scale

0.664

High

1049156

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.621

High

881775

DHYS
Deoxyhypusine synthase

2

1

High-throughput

0.611

High

1144547

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

1

High-throughput

0.606

High

771886

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.586

High

1144542

TRI11
E3 ubiquitin-protein ligase TRIM11

2

0

High-throughput

0.585

High

343950

HS74L
Heat shock 70 kDa protein 4L

2

6

High-throughput

0.584

High

484143

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

385764

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

3

High-throughput

0.571

High

452266

PDIA1
Protein disulfide-isomerase

2

14

High-throughput

0.571

High

532597

CH60
60 kDa heat shock protein, mitochondrial

2

4

High-throughput

0.571

High

573486

ENPL
Endoplasmin

2

2

High-throughput

0.571

High

610672

TCPA
T-complex protein 1 subunit alpha

2

5

High-throughput

0.571

High

620380

NUCL
Nucleolin

2

2

High-throughput

0.571

High

821362

TCPZ
T-complex protein 1 subunit zeta

2

6

High-throughput

0.571

High

841748

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

3

High-throughput

0.571

High

875972

TCPE
T-complex protein 1 subunit epsilon

2

7

High-throughput

0.571

High

881936

TCPG
T-complex protein 1 subunit gamma

2

7

High-throughput

0.571

High

899049

TCPQ
T-complex protein 1 subunit theta

2

9

High-throughput

0.571

High

899395

TCPD
T-complex protein 1 subunit delta

2

6

High-throughput

0.571

High

993184

ACTG
Actin, cytoplasmic 2

2

4

High-throughput

0.571

High

1007027

TCPB
T-complex protein 1 subunit beta

2

6

High-throughput

0.571

High

1143127

PLEC
Plectin

2

2

High-throughput

0.571

High

1144543

TCPH
T-complex protein 1 subunit eta

2

7

High-throughput

0.571

High

1144544

GRWD1
Glutamate-rich WD repeat-containing protein 1

2

2

High-throughput

0.571

High

1144550

DDX28
Probable ATP-dependent RNA helicase DDX28

2

4

High-throughput

0.571

High

1144553

KCTD5
BTB/POZ domain-containing protein KCTD5

2

10

High-throughput

0.571

High

1144555

COR1C
Coronin-1C

2

5

High-throughput

0.571

High

1097137

MK07
Mitogen-activated protein kinase 7

1

20

Small-scale

0.561

High

290933

PPM1B
Protein phosphatase 1B

2

0

High-throughput

0.547

High

660070

COF1
Cofilin-1

2

0

High-throughput

0.547

High

724754

METK2
S-adenosylmethionine synthase isoform type-2

2

0

High-throughput

0.547

High

1011613

RT35
Small ribosomal subunit protein mS35

2

0

High-throughput

0.547

High

1040132

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

2

0

High-throughput

0.547

High

1144528

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

2

0

High-throughput

0.547

High

1144534

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

2

0

High-throughput

0.547

High

1144540

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

2

0

High-throughput

0.547

High

1144541

PTCD3
Small ribosomal subunit protein mS39

2

0

High-throughput

0.547

High

1144546

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

0

High-throughput

0.547

High

1144548

BOLA2
BolA-like protein 2

2

0

High-throughput

0.547

High

1144549

SYFB
Phenylalanine--tRNA ligase beta subunit

2

0

High-throughput

0.547

High

1144552

ARGL1
Arginine and glutamate-rich protein 1

2

0

High-throughput

0.547

High

1112292

PWP1
Periodic tryptophan protein 1 homolog

2

2

High-throughput

0.521

High

1144530

RL22L
Ribosomal protein eL22-like

2

2

High-throughput

0.521

High

1144532

DDX46
Probable ATP-dependent RNA helicase DDX46

2

2

High-throughput

0.521

High

1144551

ATD3A
ATPase family AAA domain-containing protein 3A

2

7

High-throughput

0.521

High

1144554

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.506

High

1144539

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

8

Small-scale

0.501

High

791400

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

176985

CE290
Centrosomal protein of 290 kDa

1

8

High-throughput

0.479

High

273528

DJC13
DnaJ homolog subfamily C member 13

1

3

High-throughput

0.479

High

445893

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

761688

HSP74
Heat shock 70 kDa protein 4

1

6

High-throughput

0.479

High

931664

RD23B
UV excision repair protein RAD23 homolog B

1

3

High-throughput

0.479

High

1144525

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.479

High

1144527

MAPK3
MAP kinase-activated protein kinase 3

1

5

High-throughput

0.479

High

1144537

TBCD5
TBC1 domain family member 5

1

2

High-throughput

0.479

High

1144556

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

High-throughput

0.479

High

1144557

SNX6
Sorting nexin-6

1

1

High-throughput

0.479

High

317844

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

1085168

WASC5
WASH complex subunit 5

1

0

High-throughput

0.458

High

618253

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

837627

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

1136732

MD2BP
MAD2L1-binding protein

1

1

High-throughput

0.437

High

1144535

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

3

High-throughput

0.437

High

837397

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

1

High-throughput

0.407

High

256301

RT14
Small ribosomal subunit protein uS14m

2

0

High-throughput

0.298

High

643853

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.298

High

939785

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

2

0

High-throughput

0.298

High

1011089

RT22
Small ribosomal subunit protein mS22

2

0

High-throughput

0.298

High

1011798

RT05
Small ribosomal subunit protein uS5m

2

0

High-throughput

0.298

High

1012321

RT15
Small ribosomal subunit protein uS15m

2

0

High-throughput

0.298

High

1012505

RT34
Small ribosomal subunit protein mS34

2

0

High-throughput

0.298

High

1144529

K1614
Uncharacterized protein KIAA1614

2

0

High-throughput

0.298

High

1144536

RT27
Small ribosomal subunit protein mS27

2

0

High-throughput

0.298

High

1144538

RT31
Small ribosomal subunit protein mS31

2

0

High-throughput

0.298

High

1144545

MMTA2
Multiple myeloma tumor-associated protein 2

2

0

High-throughput

0.298

High

1144558

RT33
Small ribosomal subunit protein mS33

2

0

High-throughput

0.298

High

1144559

RT28
Small ribosomal subunit protein bS1m

2

0

High-throughput

0.298

High

1144560

RT07
Small ribosomal subunit protein uS7m

2

0

High-throughput

0.298

High

1144561

RT02
Small ribosomal subunit protein uS2m

2

0

High-throughput

0.298

High

1144562

RT23
Small ribosomal subunit protein mS23

2

0

High-throughput

0.298

High

932874

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.279

Low

1144524

SSXT
Protein SSXT

1

0

High-throughput

0.279

Low

177546

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025