HitPredict

Interactor 1: PER1 (O15534)
Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
Gene: PER1

Interactor 2: KC1E (P49674)
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
Gene: CSNK1E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	10848614, 15917222, 23555304, 26496610, 28514442, 33961781, 32707033, 23455922, 16790549
Identification Methods	affinity chromatography technology, pull down, two hybrid, enzymatic study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032922 - circadian regulation of gene expression and 1 others more... GO:0042752 - regulation of circadian rhythm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 416
+	Mm
		193662 PER1_MOUSE (1-1290): 1.01e-164: 528: 90.40		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Mm
		193658 PER1_MOUSE (1-1290): 1.01e-164: 528: 90.40		KC1A_MOUSE (2-326): 1.03e-134: 391: 69.54
+	Hs
		182324 PER1_HUMAN (1-1290): 2.25e-166: 532: 100.00		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Mm
		193661 PER1_MOUSE (1-1290): 1.01e-164: 528: 90.40		KC1D_MOUSE (1-406): 1.2e-125: 371: 83.50
+	Hs
		182338 PER1_HUMAN (1-1290): 2.25e-166: 532: 100.00		KC1G2_HUMAN (3-348): 3.73e-119: 354: 50.28
+	Hs
		165951 PER2_HUMAN (26-1242): 5.25e-133: 441: 37.84		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		165949 PER2_HUMAN (26-1242): 5.25e-133: 441: 37.84		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Mm
		1337560 BMAL1_MOUSE (32-648): 9.56e-119: 385: 15.96		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Mm
		222713 PER2_MOUSE (26-1239): 7.66e-112: 383: 36.55		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Mm
		222703 PER2_MOUSE (26-1239): 7.66e-112: 383: 36.55		KC1A_MOUSE (2-326): 1.03e-134: 391: 69.54
+	Hs
		126110 BMAL1_HUMAN (32-648): 3.6e-113: 370: 16.09		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		822275 HIF1A_HUMAN (112-867): 4.44e-119: 392: 11.63		KC1D_HUMAN (1-406): 2e-125: 370: 83.25
+	Mm
		222711 PER2_MOUSE (26-1239): 7.66e-112: 383: 36.55		KC1D_MOUSE (1-406): 1.2e-125: 371: 83.50
+	Hs
		681876 HIF1A_HUMAN (112-867): 4.44e-119: 392: 11.63		AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56
+	Hs
		830317 PER3_HUMAN (125-1216): 3.65e-90: 319: 33.50		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Hs
		649042 ARNT_HUMAN (23-772): 1.94e-104: 351: 15.54		AKT1_HUMAN (5-356): 7.92e-119: 356: 18.56
+	Hs
		181505 CLOCK_HUMAN (103-949): 9.56e-87: 303: 11.52		KC1E_HUMAN (1-416): 1.42e-136: 399: 100.00
+	Dm
		1096079 TRH_DROME (125-952): 5.85e-94: 327: 15.48		AKT1_DROME (1-356): 5.01e-119: 361: 16.76
+	Mm
		139877 CLOCK_MOUSE (103-925): 1.89e-82: 291: 11.27		KC1E_MOUSE (1-416): 8.22e-136: 397: 98.80
+	Dm
		283732 PER_DROME (217-575): 3.72e-76: 278: 27.20		DCO_DROME (1-339): 2.92e-115: 345: 77.29