HitPredict

Interactor 1: CKS1 (O23249)
Cyclin-dependent kinases regulatory subunit 1 (CKS1-At)
Gene: CKS1

Interactor 2: CKB12 (Q2V419)
Cyclin-dependent kinase B1-2 (CDKB1;2) (EC 2.7.11.22) (EC 2.7.11.23)
Gene: CDKB1-2

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.852

Property	Details
Experiments	20407024, 20706207, 11432958
Identification Methods	protein complementation assay, two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005737 - cytoplasm GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 87 At			1 311
+	At
		1103378 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB12_ARATH (1-311): 1.9e-146: 415: 100.00
+	At
		188137 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB11_ARATH (1-311): 3.89e-139: 397: 87.78
+	Hs
		625283 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK2_HUMAN (1-309): 2.25e-149: 422: 56.77
+	At
		188136 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CDKA1_ARATH (1-306): 1.17e-137: 392: 55.05
+	At
		639376 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB11_ARATH (1-311): 3.89e-139: 397: 87.78
+	At
		188156 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB21_ARATH (1-310): 1.14e-135: 388: 62.26
+	At
		188157 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CKB22_ARATH (1-310): 1.61e-134: 385: 64.19
+	At
		621728 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKA1_ARATH (1-306): 1.17e-137: 392: 55.05
+	At
		1227962 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB21_ARATH (1-310): 1.14e-135: 388: 62.26
+	At
		1228093 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CKB22_ARATH (1-310): 1.61e-134: 385: 64.19
+	Hs
		895413 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK3_HUMAN (1-309): 9.3e-142: 403: 56.77
+	Hs
		414843 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK1_HUMAN (1-308): 5.61e-135: 386: 54.05
+	At
		1321299 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKD1_ARATH (2-309): 4.43e-123: 359: 39.61
+	Dm
		618415 Q9VHN1_DROME (2-71): 2.35e-37: 122: 70.00		CDK1_DROME (1-307): 1.25e-129: 372: 51.30
+	Dm
		618387 CKS1_DROME (3-71): 5.27e-35: 115: 66.67		CDK1_DROME (1-307): 1.25e-129: 372: 51.30
+	Hs
		895414 CKS1_HUMAN (3-77): 1.31e-35: 117: 64.00		CDK5_HUMAN (1-309): 5.66e-129: 370: 50.48
+	Dm
		618471 Q9VHN1_DROME (2-71): 2.35e-37: 122: 70.00		CDK2_DROME (1-310): 2.72e-124: 359: 47.59
+	At
		188163 CKS1_ARATH (1-87): 6.02e-46: 143: 100.00		CDKD2_ARATH (1-305): 5.43e-113: 332: 40.66
+	Ce
		712291 CKS1_CAEEL (3-76): 2.05e-40: 129: 59.46		CDK1_CAEEL (1-311): 4.24e-116: 339: 44.20
+	At
		1321252 CKS2_ARATH (1-80): 7.09e-43: 135: 90.00		CDKD2_ARATH (1-305): 5.43e-113: 332: 40.66