HitPredict

Interactor 1: STX7 (O15400)
Syntaxin-7
Gene: STX7

Interactor 2: YKT6 (O15498)
Synaptobrevin homolog YKT6 (EC 2.3.1.-)
Gene: YKT6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	26186194, 28514442, 34079125, 33961781, 33422265
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005768 - endosome GO:0005886 - plasma membrane GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 198
+	Dm
		1174554 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		Q9W3M8_DROME (1-196): 4.64e-71: 215: 61.74
+	Hs
		189347 STX7_HUMAN (1-261): 9.29e-70: 217: 100.00		SC22B_HUMAN (1-196): 1.74e-63: 197: 19.60
+	Mm
		999984 Q8BH40_MOUSE (1-259): 1.02e-74: 229: 94.98		VAMP7_MOUSE (28-193): 4.5e-57: 180: 22.60
+	Hs
		192275 STX12_HUMAN (10-244): 3.43e-58: 188: 54.01		YKT6_HUMAN (1-198): 1.05e-72: 219: 100.00
+	Hs
		280135 STX2_HUMAN (7-256): 2.05e-65: 207: 27.13		SC22B_HUMAN (1-196): 1.74e-63: 197: 19.60
+	Mm
		147440 STX1A_MOUSE (7-259): 3.2e-65: 206: 24.90		SC22B_MOUSE (1-196): 1.74e-63: 197: 19.60
+	Hs
		280213 STX1A_HUMAN (6-259): 6.07e-65: 205: 24.05		SC22B_HUMAN (1-196): 1.74e-63: 197: 19.60
+	At
		1020624 SYP22_ARATH (3-245): 3.88e-59: 190: 29.63		VA721_ARATH (22-194): 1.63e-68: 210: 21.51
+	Hs
		189469 STX7_HUMAN (1-261): 9.29e-70: 217: 100.00		VAMP7_HUMAN (28-193): 4.21e-57: 180: 22.03
+	Dm
		121793 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		M9PGI6_DROME (3-195): 2.32e-59: 186: 21.03
+	Rn
		746118 STX1A_RAT (7-259): 2.78e-65: 206: 24.90		VAMP7_RAT (28-193): 1.97e-57: 182: 23.16
+	Hs
		280246 STX12_HUMAN (10-244): 3.43e-58: 188: 54.01		SC22B_HUMAN (1-196): 1.74e-63: 197: 19.60
+	Dm
		305560 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		O77434_DROME (3-195): 3.21e-58: 183: 20.00
+	Hs
		908014 STX1A_HUMAN (6-259): 6.07e-65: 205: 24.05		VAMP7_HUMAN (28-193): 4.21e-57: 180: 22.03
+	Dm
		1174524 STX1A_DROME (1-256): 1.06e-63: 202: 22.73		Q7JYX5_DROME (28-194): 4.06e-54: 173: 25.84
+	At
		235605 SYP22_ARATH (3-245): 3.88e-59: 190: 29.63		VA711_ARATH (28-193): 1.17e-56: 179: 20.79
+	At
		1020603 SYP22_ARATH (3-245): 3.88e-59: 190: 29.63		VA713_ARATH (27-192): 3.55e-56: 178: 21.23
+	At
		1020601 SYP22_ARATH (3-245): 3.88e-59: 190: 29.63		VA714_ARATH (28-193): 2.37e-53: 171: 17.88
+	Hs
		746216 STX2_HUMAN (7-256): 2.05e-65: 207: 27.13		SC22A_HUMAN (1-147): 4.74e-29: 111: 16.23
+	Hs
		1159623 STX1A_HUMAN (6-259): 6.07e-65: 205: 24.05		SC22A_HUMAN (1-147): 4.74e-29: 111: 16.23