HitPredict

Interactor 1: SH3G3 (O35180)
Endophilin-A3 (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) (SH3p13)
Gene: Sh3gl3

Interactor 2: DYN1 (P21575)
Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin I) (Dynamin, brain)
Gene: Dnm1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	9238017
Identification Methods	far western blotting, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 347 Rn			1 864
+	Mm
		760455 SH3G3_MOUSE (1-346): 7.89e-96: 290: 94.80		DYN1_MOUSE (1-845): 0: 1065: 98.34
+	Hs
		983405 SH3G2_HUMAN (1-347): 1.94e-88: 271: 66.19		DYN1_HUMAN (1-864): 0: 1071: 98.03
+	Rn
		192351 SH3G2_RAT (1-347): 3.37e-88: 270: 65.34		DYN1_RAT (1-864): 0: 1067: 100.00
+	Mm
		760454 SH3G2_MOUSE (1-347): 2.96e-88: 271: 65.91		DYN1_MOUSE (1-845): 0: 1065: 98.34
+	Hs
		983404 SH3G1_HUMAN (1-347): 4.74e-84: 260: 63.04		DYN1_HUMAN (1-864): 0: 1071: 98.03
+	Rn
		193636 SH3G1_RAT (1-347): 4.8e-83: 258: 63.04		DYN1_RAT (1-864): 0: 1067: 100.00
+	Mm
		760453 SH3G1_MOUSE (1-347): 1.74e-83: 259: 62.77		DYN1_MOUSE (1-845): 0: 1065: 98.34
+	Hs
		840808 SH3G3_HUMAN (1-347): 2.39e-95: 288: 86.74		DYN2_HUMAN (1-860): 0: 997: 77.54
+	Mm
		760467 SHLB1_MOUSE (10-342): 1.48e-67: 218: 23.93		DYN1_MOUSE (1-845): 0: 1065: 98.34
+	Hs
		1307464 SH3G3_HUMAN (1-347): 2.39e-95: 288: 86.74		DYN3_HUMAN (1-860): 0: 989: 77.43
+	Hs
		840807 SH3G2_HUMAN (1-347): 1.94e-88: 271: 66.19		DYN2_HUMAN (1-860): 0: 997: 77.54
+	Hs
		1307442 SH3G2_HUMAN (1-347): 1.94e-88: 271: 66.19		DYN3_HUMAN (1-860): 0: 989: 77.43
+	Hs
		840806 SH3G1_HUMAN (1-347): 4.74e-84: 260: 63.04		DYN2_HUMAN (1-860): 0: 997: 77.54
+	Hs
		1307425 SH3G1_HUMAN (1-347): 4.74e-84: 260: 63.04		DYN3_HUMAN (1-860): 0: 989: 77.43
+	Dm
		649303 SH3G3_DROME (1-346): 1.31e-70: 226: 48.64		DYN_DROME (6-859): 0: 953: 65.07
+	Mm
		760473 SRC8_MOUSE (7-343): 1.06e-49: 175: 12.94		DYN2_MOUSE (1-860): 0: 995: 77.99
+	Hs
		840692 SRC8_HUMAN (7-343): 2.13e-46: 167: 14.20		DYN2_HUMAN (1-860): 0: 997: 77.54
+	Ce
		70029 SH3GH_CAEEL (1-345): 5.19e-69: 222: 43.19		DYN1_CAEEL (3-783): 0: 910: 65.01
+	Hs
		128631 SH3G1_HUMAN (1-347): 4.74e-84: 260: 63.04		DNM1L_HUMAN (6-750): 0: 756: 38.77
+	Hs
		128646 SHLB2_HUMAN (10-342): 6.52e-61: 202: 21.88		DNM1L_HUMAN (6-750): 0: 756: 38.77