HitPredict

Interactor 1: PBX3 (O35317)
Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)
Gene: PBX3

Interactor 2: PKNX2 (Q8BG99)
Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)
Gene: Pknox2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeobox_KN
Common GO terms	GO:0005634 - nucleus GO:0043565 - sequence-specific DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 434 Mm			1 474
+	Hs
		823973 PBX3_HUMAN (1-434): 7.6e-156: 449: 99.77		PKNX2_HUMAN (1-474): 5.61e-131: 389: 98.52
+	Mm
		835791 PBX1_MOUSE (1-434): 5.72e-136: 398: 82.07		PKNX2_MOUSE (1-474): 1.17e-133: 396: 100.00
+	Hs
		823858 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		PKNX2_HUMAN (1-474): 5.61e-131: 389: 98.52
+	Hs
		163417 PBX3_HUMAN (1-434): 7.6e-156: 449: 99.77		MEIS2_HUMAN (1-467): 1.19e-101: 314: 29.23
+	Mm
		204673 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		MEIS2_MOUSE (1-443): 7.15e-102: 314: 30.00
+	Mm
		204675 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		MEIS1_MOUSE (1-371): 5.1e-103: 314: 35.68
+	Mm
		204663 PBX3_MOUSE (1-434): 2.52e-155: 448: 100.00		PKNX1_MOUSE (13-474): 1.24e-99: 307: 56.66
+	Hs
		823930 PBX3_HUMAN (1-434): 7.6e-156: 449: 99.77		PKNX1_HUMAN (13-474): 6.32e-98: 303: 56.24
+	Mm
		205767 PBX2_MOUSE (43-434): 1.39e-118: 354: 79.44		PKNX2_MOUSE (1-474): 1.17e-133: 396: 100.00
+	Hs
		137124 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		MEIS1_HUMAN (1-371): 2.06e-103: 315: 35.68
+	Hs
		163415 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		MEIS2_HUMAN (1-467): 1.19e-101: 314: 29.23
+	Mm
		835786 PBX1_MOUSE (1-434): 5.72e-136: 398: 82.07		MEIS2_MOUSE (1-443): 7.15e-102: 314: 30.00
+	Mm
		835789 PBX1_MOUSE (1-434): 5.72e-136: 398: 82.07		MEIS1_MOUSE (1-371): 5.1e-103: 314: 35.68
+	Mm
		267132 PBX1_MOUSE (1-434): 5.72e-136: 398: 82.07		PKNX1_MOUSE (13-474): 1.24e-99: 307: 56.66
+	Hs
		823829 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		PKNX1_HUMAN (13-474): 6.32e-98: 303: 56.24
+	Mm
		205764 PBX2_MOUSE (43-434): 1.39e-118: 354: 79.44		MEIS2_MOUSE (1-443): 7.15e-102: 314: 30.00
+	Mm
		205765 PBX2_MOUSE (43-434): 1.39e-118: 354: 79.44		MEIS1_MOUSE (1-371): 5.1e-103: 314: 35.68
+	Mm
		205761 PBX2_MOUSE (43-434): 1.39e-118: 354: 79.44		PKNX1_MOUSE (13-474): 1.24e-99: 307: 56.66
+	Hs
		823926 PBX3_HUMAN (1-434): 7.6e-156: 449: 99.77		PBX3_HUMAN (28-473): 1.4e-49: 176: 15.52
+	Hs
		823822 PBX1_HUMAN (1-434): 5.72e-136: 398: 82.07		PBX2_HUMAN (171-473): 8.6e-51: 180: 17.26