HitPredict

Interactor 1: PBX1 (P40424)
Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)
Gene: PBX1

Interactor 2: PKNX2 (Q96KN3)
Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2)
Gene: PKNOX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	33961781, 20211142
Identification Methods	affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Homeobox_KN~Homeobox_KN
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 430 Hs			1 472
+	Mm
		835791 PBX1_MOUSE (1-430): 2.7e-149: 432: 100.00		PKNX2_MOUSE (1-472): 6.55e-130: 386: 97.89
+	Hs
		823973 PBX3_HUMAN (1-430): 1.27e-142: 416: 81.32		PKNX2_HUMAN (1-472): 5.01e-131: 389: 100.00
+	Mm
		204676 PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55		PKNX2_MOUSE (1-472): 6.55e-130: 386: 97.89
+	Mm
		205767 PBX2_MOUSE (40-430): 3.5e-123: 366: 80.10		PKNX2_MOUSE (1-472): 6.55e-130: 386: 97.89
+	Mm
		835786 PBX1_MOUSE (1-430): 2.7e-149: 432: 100.00		MEIS2_MOUSE (1-464): 7.53e-103: 317: 29.50
+	Hs
		163415 PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00		MEIS2_HUMAN (1-464): 2.28e-102: 315: 29.50
+	Hs
		137124 PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00		MEIS1_HUMAN (1-383): 9.97e-103: 314: 35.10
+	Mm
		835789 PBX1_MOUSE (1-430): 2.7e-149: 432: 100.00		MEIS1_MOUSE (1-383): 1.06e-102: 314: 35.10
+	Hs
		163417 PBX3_HUMAN (1-430): 1.27e-142: 416: 81.32		MEIS2_HUMAN (1-464): 2.28e-102: 315: 29.50
+	Mm
		204673 PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55		MEIS2_MOUSE (1-464): 7.53e-103: 317: 29.50
+	Mm
		267132 PBX1_MOUSE (1-430): 2.7e-149: 432: 100.00		PKNX1_MOUSE (13-472): 1.44e-96: 299: 56.90
+	Mm
		204675 PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55		MEIS1_MOUSE (1-383): 1.06e-102: 314: 35.10
+	Hs
		823829 PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00		PKNX1_HUMAN (13-472): 1.03e-94: 295: 56.48
+	Mm
		204663 PBX3_MOUSE (1-430): 5.28e-142: 414: 81.55		PKNX1_MOUSE (13-472): 1.44e-96: 299: 56.90
+	Hs
		823930 PBX3_HUMAN (1-430): 1.27e-142: 416: 81.32		PKNX1_HUMAN (13-472): 1.03e-94: 295: 56.48
+	Mm
		205764 PBX2_MOUSE (40-430): 3.5e-123: 366: 80.10		MEIS2_MOUSE (1-464): 7.53e-103: 317: 29.50
+	Mm
		205765 PBX2_MOUSE (40-430): 3.5e-123: 366: 80.10		MEIS1_MOUSE (1-383): 1.06e-102: 314: 35.10
+	Mm
		205761 PBX2_MOUSE (40-430): 3.5e-123: 366: 80.10		PKNX1_MOUSE (13-472): 1.44e-96: 299: 56.90
+	Hs
		823822 PBX1_HUMAN (1-430): 2.7e-149: 432: 100.00		PBX2_HUMAN (238-470): 3.73e-49: 175: 20.25
+	Hs
		823926 PBX3_HUMAN (1-430): 1.27e-142: 416: 81.32		PBX3_HUMAN (260-470): 7.28e-48: 172: 21.68