Protein: PKNX1
Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1)

Gene: PKNX1, PKNOX1
Organism: Homo sapiens
Interactions: 71
UniProt ID: P55347

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001525 - angiogenesis
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

823829

PBX1
Pre-B-cell leukemia transcription factor 1

11

20

Small-scale

0.978

High

823874

PBX2
Pre-B-cell leukemia transcription factor 2

6

19

Small-scale

0.945

High

938182

PBX4
Pre-B-cell leukemia transcription factor 4

5

20

High-throughput

0.926

High

823930

PBX3
Pre-B-cell leukemia transcription factor 3

2

20

Small-scale

0.785

High

184766

SHOX
Short stature homeobox protein

1

20

High-throughput

0.691

High

687171

HMGB2
High mobility group protein B2

4

11

High-throughput

0.683

High

576196

PO2F1
POU domain, class 2, transcription factor 1

1

6

Small-scale

0.681

High

938162

FHL2
Four and a half LIM domains protein 2

3

3

High-throughput

0.665

High

685140

PAX6
Paired box protein Pax-6

1

11

Small-scale

0.647

High

885195

HXA1
Homeobox protein Hox-A1

1

20

Small-scale

0.647

High

938181

NUP58
Nucleoporin p58/p45

4

3

High-throughput

0.637

High

938158

TRAF1
TNF receptor-associated factor 1

2

4

High-throughput

0.628

High

63179

VP37C
Vacuolar protein sorting-associated protein 37C

4

3

High-throughput

0.623

High

123359

BACH
Cytosolic acyl coenzyme A thioester hydrolase

2

0

High-throughput

0.602

High

163420

MEIS2
Homeobox protein Meis2

1

19

Small-scale

0.590

High

139391

VMA5A
von Willebrand factor A domain-containing protein 5A

2

5

High-throughput

0.574

High

938178

CC120
Coiled-coil domain-containing protein 120

2

6

High-throughput

0.574

High

938160

MPP3
MAGUK p55 subfamily member 3

2

1

High-throughput

0.553

High

938172

F110B
Protein FAM110B

2

3

High-throughput

0.553

High

938173

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

2

2

High-throughput

0.553

High

245896

KIF1B
Kinesin-like protein KIF1B

1

2

High-throughput

0.541

High

258373

GAS7
Growth arrest-specific protein 7

1

1

High-throughput

0.541

High

272634

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

4

High-throughput

0.541

High

668542

APC
Adenomatous polyposis coli protein

1

5

High-throughput

0.541

High

674118

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.541

High

838036

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.541

High

838224

STAT6
Signal transducer and activator of transcription 6

1

1

High-throughput

0.541

High

873933

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

923576

TTC3
E3 ubiquitin-protein ligase TTC3

1

1

High-throughput

0.541

High

938152

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

High-throughput

0.541

High

938154

EF1A2
Elongation factor 1-alpha 2

1

1

High-throughput

0.541

High

938156

KIF1A
Kinesin-like protein KIF1A

1

1

High-throughput

0.541

High

938159

CENPR
Centromere protein R

1

2

High-throughput

0.541

High

938170

CMYA5
Cardiomyopathy-associated protein 5

1

4

High-throughput

0.541

High

938174

ANR49
Ankyrin repeat domain-containing protein 49

1

4

High-throughput

0.541

High

938184

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

2

High-throughput

0.541

High

938187

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

1

High-throughput

0.541

High

938189

BAIP2
BAR/IMD domain-containing adapter protein 2

1

2

High-throughput

0.541

High

938171

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.536

High

938165

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.529

High

215991

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.518

High

344904

WIZ
Protein Wiz

1

0

High-throughput

0.518

High

871774

RFX3
Transcription factor RFX3

1

0

High-throughput

0.518

High

938163

CAPR1
Caprin-1

1

0

High-throughput

0.518

High

938185

BEX4
Protein BEX4

1

0

High-throughput

0.518

High

938186

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.518

High

167244

KLF11
Krueppel-like factor 11

1

5

High-throughput

0.515

High

487140

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

421798

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

176337

SYNEM
Synemin

1

1

High-throughput

0.494

High

486869

C1S
Complement C1s subcomponent

1

1

High-throughput

0.494

High

938164

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.494

High

938167

RFIP4
Rab11 family-interacting protein 4

1

3

High-throughput

0.494

High

938168

TRI59
Tripartite motif-containing protein 59

1

2

High-throughput

0.494

High

938188

EXOC7
Exocyst complex component 7

1

2

High-throughput

0.494

High

938166

CE024
UPF0461 protein C5orf24

1

5

High-throughput

0.489

High

938169

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.481

High

473885

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

938155

MN1
Transcriptional activator MN1

1

1

Small-scale

0.479

High

938157

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.479

High

938175

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

938180

TBX5
T-box transcription factor TBX5

1

13

High-throughput

0.479

High

938153

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

366481

UROK
Urokinase-type plasminogen activator

1

2

Small-scale

0.437

High

938190

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.437

High

938183

VPS16
Vacuolar protein sorting-associated protein 16 homolog

3

0

High-throughput

0.347

High

938177

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

762228

TRY3
Trypsin-3

1

0

High-throughput

0.282

High

938161

TCOF
Treacle protein

1

0

High-throughput

0.282

High

938179

FMNL2
Formin-like protein 2

1

0

High-throughput

0.282

High

938176

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025