HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: EED (Q921E6)
Polycomb protein EED
Gene: EED

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001739 - sex chromatin GO:0003682 - chromatin binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 441
+	Hs
		285230 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		EED_HUMAN (1-441): 1.63e-90: 283: 100.00
+	Mm
		1362630 RING2_MOUSE (8-406): 2.2e-98: 298: 54.25		EED_MOUSE (1-441): 1.63e-90: 283: 100.00
+	Hs
		285431 RING2_HUMAN (8-406): 3.36e-98: 298: 54.25		EED_HUMAN (1-441): 1.63e-90: 283: 100.00
+	Hs
		285107 PCGF2_HUMAN (31-378): 9.31e-64: 209: 16.67		EED_HUMAN (1-441): 1.63e-90: 283: 100.00
+	Mm
		662910 PCGF2_MOUSE (31-378): 1.03e-59: 199: 16.94		EED_MOUSE (1-441): 1.63e-90: 283: 100.00
+	Mm
		1296652 RING2_MOUSE (8-406): 2.2e-98: 298: 54.25		TBL1R_MOUSE (25-267): 9.4e-48: 172: 14.40
+	Hs
		1404746 RING2_HUMAN (8-406): 3.36e-98: 298: 54.25		TBL1R_HUMAN (25-267): 1.29e-47: 172: 14.40
+	Hs
		285106 BMI1_HUMAN (31-370): 4.29e-51: 176: 15.07		EED_HUMAN (1-441): 1.63e-90: 283: 100.00
+	Mm
		683129 BMI1_MOUSE (31-370): 1.42e-49: 172: 14.87		EED_MOUSE (1-441): 1.63e-90: 283: 100.00
+	Mm
		1341427 PCGF1_MOUSE (25-130): 1.17e-38: 141: 24.77		EED_MOUSE (1-441): 1.63e-90: 283: 100.00
+	Hs
		285443 PCGF1_HUMAN (25-130): 8.97e-39: 141: 24.77		EED_HUMAN (1-441): 1.63e-90: 283: 100.00
+	Hs
		1380110 RING2_HUMAN (8-406): 3.36e-98: 298: 54.25		FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32
+	Hs
		964879 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09
+	Hs
		965178 RING2_HUMAN (8-406): 3.36e-98: 298: 54.25		WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09
+	Mm
		965403 RING2_MOUSE (8-406): 2.2e-98: 298: 54.25		WDR5_MOUSE (335-440): 3.34e-14: 75.4: 15.09
+	Hs
		623473 RO52_HUMAN (33-307): 1.35e-43: 159: 13.46		FBXW7_HUMAN (219-439): 2.95e-26: 113: 15.32
+	Hs
		965185 BARD1_HUMAN (4-352): 2.6e-50: 183: 15.55		WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09
+	Hs
		765316 BMI1_HUMAN (31-370): 4.29e-51: 176: 15.07		WDR5_HUMAN (335-440): 3.34e-14: 75.4: 15.09
+	Hs
		209207 BMI1_HUMAN (31-370): 4.29e-51: 176: 15.07		PRP4_HUMAN (332-437): 4.05e-09: 60.4: 15.79
+	Hs
		623587 RO52_HUMAN (33-307): 1.35e-43: 159: 13.46		FBW1B_HUMAN (160-352): 1.57e-12: 71.3: 18.97