HitPredict

Interactor 1: TNF14 (O43557)
Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
Gene: TNFSF14

Interactor 2: TNR14 (Q92956)
Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
Gene: TNFRSF14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.943

The method score is based on:

Property Details
Experiments 11390428, 10318773, 10799510, 11164894, 26977880, 9462508
Identification Methods pull down, affinity chromatography technology, solid phase assay, enzyme linked immunosorbent assay, fluorescence-activated cell sorting, yeast display
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNFR_c6
Common GO terms GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0031295 - T cell costimulation
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 240
Hs

1 283
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024