HitPredict

Interactor 1: FRS3 (O43559)
Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FGFR-signaling adaptor SNT2) (Suc1-associated neurotrophic factor target 2) (SNT-2)
Gene: FRS3

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23279575
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 492 Hs			1 1255
+	Hs
		338745 FRS2_HUMAN (1-492): 0: 598: 45.98		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		383949 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383858 DOK6_HUMAN (34-182): 2.07e-49: 174: 26.38		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383894 DOK4_HUMAN (34-178): 6.07e-39: 145: 22.75		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		338891 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338618 DOK3_HUMAN (20-281): 5.12e-67: 225: 19.20		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338574 DOK6_HUMAN (34-182): 2.07e-49: 174: 26.38		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		338739 DOK4_HUMAN (34-178): 6.07e-39: 145: 22.75		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		434249 FRS2_HUMAN (1-492): 0: 598: 45.98		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Hs
		872680 FRS2_HUMAN (1-492): 0: 598: 45.98		EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45
+	Hs
		411450 FRS2_HUMAN (1-492): 0: 598: 45.98		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		434273 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Mm
		337623 DOK1_MOUSE (19-309): 8.07e-67: 224: 20.42		ABL1_MOUSE (710-1254): 3.84e-121: 405: 24.43
+	Hs
		411486 DOK1_HUMAN (19-309): 5.76e-79: 256: 20.48		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		434219 DOK6_HUMAN (34-182): 2.07e-49: 174: 26.38		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Mm
		337639 DOK3_MOUSE (19-281): 3.72e-48: 173: 20.85		ABL1_MOUSE (710-1254): 3.84e-121: 405: 24.43
+	Hs
		434248 DOK4_HUMAN (34-178): 6.07e-39: 145: 22.75		RET_HUMAN (426-1088): 3.53e-131: 432: 23.33
+	Mm
		956526 DOK1_MOUSE (19-309): 8.07e-67: 224: 20.42		FAK2_MOUSE (707-1006): 9.29e-54: 207: 36.42
+	Mm
		546269 DOK1_MOUSE (19-309): 8.07e-67: 224: 20.42		INSR_MOUSE (357-634): 8.32e-17: 88.7: 19.54
+	Mm
		546280 DOK3_MOUSE (19-281): 3.72e-48: 173: 20.85		INSR_MOUSE (357-634): 8.32e-17: 88.7: 19.54