HitPredict

Interactor 1: ADA12 (O43184)
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)
Gene: ADAM12

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25825872
Identification Methods	peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 909 Hs			1 217
+	Mm
		1221222 ADA12_MOUSE (29-909): 0: 609: 80.82		GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54
+	Hs
		209894 ADA12_HUMAN (1-909): 0: 658: 100.00		SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14
+	Hs
		209914 ADA12_HUMAN (1-909): 0: 658: 100.00		ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92
+	Hs
		209868 ADA12_HUMAN (1-909): 0: 658: 100.00		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		209891 ADA12_HUMAN (1-909): 0: 658: 100.00		ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53
+	Hs
		209870 ADA12_HUMAN (1-909): 0: 658: 100.00		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90
+	Hs
		209872 ADA12_HUMAN (1-909): 0: 658: 100.00		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		209869 ADA12_HUMAN (1-909): 0: 658: 100.00		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		594096 ADA19_HUMAN (5-901): 1.23e-165: 509: 41.72		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		463504 ADAM9_HUMAN (36-774): 1.09e-174: 529: 37.37		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		473471 ADA19_HUMAN (5-901): 1.23e-165: 509: 41.72		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90
+	Hs
		557462 ADA19_HUMAN (5-901): 1.23e-165: 509: 41.72		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		463755 ADA19_HUMAN (5-901): 1.23e-165: 509: 41.72		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		440062 ADA15_HUMAN (36-880): 5.65e-133: 421: 34.32		LCK_HUMAN (3-202): 7.98e-34: 128: 28.44
+	Hs
		473479 ADA22_HUMAN (3-863): 9.78e-146: 456: 26.52		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90
+	Hs
		557217 ADAM8_HUMAN (31-855): 3.17e-147: 457: 33.69		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		362279 ADA15_HUMAN (36-880): 5.65e-133: 421: 34.32		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		463807 ADA22_HUMAN (3-863): 9.78e-146: 456: 26.52		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		440542 ADA15_HUMAN (36-880): 5.65e-133: 421: 34.32		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		463083 ADA15_HUMAN (36-880): 5.65e-133: 421: 34.32		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33