HitPredict

Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22351778
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0035357 - peroxisome proliferator activated receptor signaling pathway GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048384 - retinoic acid receptor signaling pathway
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 911 Hs			1 505
+	Hs
		368893 ACTN1_HUMAN (20-911): 0: 607: 85.76		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		211456 ACTN4_HUMAN (1-911): 0: 586: 100.00		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		521532 ACTN1_HUMAN (20-911): 0: 607: 85.76		NR1H3_HUMAN (52-501): 2.02e-104: 321: 24.78
+	Hs
		211477 ACTN4_HUMAN (1-911): 0: 586: 100.00		VDR_HUMAN (139-503): 4.55e-108: 330: 26.68
+	Hs
		521591 ACTN1_HUMAN (20-911): 0: 607: 85.76		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		211472 ACTN4_HUMAN (1-911): 0: 586: 100.00		RARA_HUMAN (45-503): 3.89e-102: 316: 25.22
+	Hs
		211633 ACTN4_HUMAN (1-911): 0: 586: 100.00		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		265854 ACTN2_HUMAN (19-911): 0: 556: 77.16		NR1I2_HUMAN (139-501): 1.19e-104: 321: 26.26
+	Hs
		993279 ACTN3_HUMAN (37-911): 0: 567: 74.51		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70
+	Hs
		369420 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		ESR1_HUMAN (1-501): 9.09e-112: 345: 19.28
+	Hs
		320227 SPTN4_HUMAN (244-822): 1.07e-13: 77.8: 11.00		ERR2_HUMAN (25-502): 1.06e-104: 321: 19.14
+	Hs
		164649 SPTN2_HUMAN (262-846): 1.08e-09: 64.7: 12.62		ESR2_HUMAN (23-502): 1.79e-98: 308: 18.70