HitPredict

Interactor 1: SIAH2 (O43255)
E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)
Gene: SIAH2

Interactor 2: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	17533377
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 324 Hs			1 621
+	Hs
		297835 SIAH1_HUMAN (28-322): 4.28e-106: 312: 75.25		PIAS2_HUMAN (1-621): 0: 811: 100.00
+	Hs
		211610 SIAH2_HUMAN (1-324): 5.58e-113: 332: 100.00		PIAS3_HUMAN (1-621): 0: 666: 55.25
+	Hs
		211523 SIAH2_HUMAN (1-324): 5.58e-113: 332: 100.00		PIAS1_HUMAN (1-621): 0: 653: 54.10
+	Hs
		1307827 SIAH1_HUMAN (28-322): 4.28e-106: 312: 75.25		PIAS3_HUMAN (1-621): 0: 666: 55.25
+	Hs
		297833 TRI50_HUMAN (72-275): 2.33e-43: 157: 20.08		PIAS2_HUMAN (1-621): 0: 811: 100.00
+	Hs
		297647 SIAH1_HUMAN (28-322): 4.28e-106: 312: 75.25		PIAS1_HUMAN (1-621): 0: 653: 54.10
+	Hs
		136650 TRAF5_HUMAN (63-237): 3.3e-36: 138: 14.72		PIAS2_HUMAN (1-621): 0: 811: 100.00
+	Hs
		297803 TRAF3_HUMAN (18-212): 5.77e-32: 126: 12.14		PIAS2_HUMAN (1-621): 0: 811: 100.00