HitPredict

Interactor 1: HTRA2 (O43464)
Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene: HTRA2

Interactor 2: BIRC8 (Q96P09)
Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis)
Gene: BIRC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 236
+	Mm
		59875 HTRA2_MOUSE (1-458): 0: 548: 84.93		BIRC7_MOUSE (1-236): 7.69e-55: 179: 30.25
+	Hs
		216775 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC7_HUMAN (1-236): 7.02e-61: 194: 33.47
+	Hs
		216825 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC6_HUMAN (1-185): 3.04e-36: 137: 20.31
+	Mm
		148450 HTRA2_MOUSE (1-458): 0: 548: 84.93		BIRC3_MOUSE (4-95): 2.39e-17: 82.3: 32.98
+	Mm
		1223895 HTRA2_MOUSE (1-458): 0: 548: 84.93		BIRC2_MOUSE (4-102): 4.24e-16: 78.9: 29.70
+	Mm
		1222125 HTRA2_MOUSE (1-458): 0: 548: 84.93		XIAP_MOUSE (3-211): 1.22e-13: 71.6: 16.90
+	Hs
		216765 HTRA2_HUMAN (1-458): 0: 527: 100.00		MYLIP_HUMAN (166-235): 7.55e-21: 92.2: 35.71
+	Hs
		216683 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC3_HUMAN (4-158): 6.1e-18: 84.3: 24.20
+	Hs
		216684 HTRA2_HUMAN (1-458): 0: 527: 100.00		BIRC2_HUMAN (4-148): 3.09e-16: 79.3: 24.49
+	Hs
		216668 HTRA2_HUMAN (1-458): 0: 527: 100.00		XIAP_HUMAN (3-211): 1.27e-13: 71.6: 15.07
+	Hs
		1013363 HTRA3_HUMAN (28-456): 5.98e-163: 469: 42.86		XIAP_HUMAN (3-211): 1.27e-13: 71.6: 15.07
+	Hs
		1022758 HTRA1_HUMAN (26-455): 5.47e-146: 427: 41.05		XIAP_HUMAN (3-211): 1.27e-13: 71.6: 15.07
+	Hs
		1013285 HTRA4_HUMAN (28-455): 1.76e-125: 374: 38.67		XIAP_HUMAN (3-211): 1.27e-13: 71.6: 15.07
+	Dm
		1173284 HTRA2_DROME (141-455): 9.93e-118: 352: 50.15		DIAP1_DROME (4-84): 7.15e-19: 86.6: 32.93
+	Dm
		1173361 HTRA2_DROME (141-455): 9.93e-118: 352: 50.15		DIAP2_DROME (1-107): 1.29e-10: 62.7: 20.18