HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ILK (Q13418)
Scaffold protein ILK (ILK-1) (ILK-2) (Inactive integrin-linked kinase) (p59ILK)
Gene: ILK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10022929
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, Ank_2~SH3_1, PK_Tyr_Ser-Thr~SH3_1, Ank_2~SH3_9, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 452
+	Hs
		439961 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Mm
		440272 P85A_MOUSE (166-379): 9.21e-25: 107: 16.36		LCK_MOUSE (167-449): 9.74e-110: 335: 21.99
+	Hs
		136254 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Hs
		439912 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Hs
		439906 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Hs
		439898 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Hs
		440002 BLK_HUMAN (7-204): 7.94e-20: 92.9: 19.80		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Hs
		439897 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		LCK_HUMAN (167-449): 1.45e-109: 334: 21.99
+	Hs
		557113 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		SRC_HUMAN (173-448): 1.45e-98: 307: 24.56
+	Hs
		462996 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		YES_HUMAN (176-448): 5.04e-98: 305: 26.60
+	Hs
		136276 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		SRC_HUMAN (173-448): 1.45e-98: 307: 24.56
+	Hs
		473361 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		SRC_HUMAN (173-448): 1.45e-98: 307: 24.56
+	Hs
		486655 FGR_HUMAN (7-155): 3.52e-23: 102: 18.54		SRC_HUMAN (173-448): 1.45e-98: 307: 24.56
+	Hs
		463302 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		SRC_HUMAN (173-448): 1.45e-98: 307: 24.56
+	Hs
		462953 FGR_HUMAN (7-155): 3.52e-23: 102: 18.54		YES_HUMAN (176-448): 5.04e-98: 305: 26.60
+	Hs
		440323 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		SRC_HUMAN (173-448): 1.45e-98: 307: 24.56
+	Hs
		462946 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		YES_HUMAN (176-448): 5.04e-98: 305: 26.60
+	Hs
		440300 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		YES_HUMAN (176-448): 5.04e-98: 305: 26.60
+	Hs
		439905 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		YES_HUMAN (176-448): 5.04e-98: 305: 26.60
+	Hs
		1154181 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		M3K20_HUMAN (188-451): 5.69e-26: 113: 27.99