Protein: M3K20
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)

Gene: M3K20, MAP3K20
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9NYL2

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

990800

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.938

High

730295

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.925

High

966948

1433G
14-3-3 protein gamma

4

20

High-throughput

0.896

High

691484

1433T
14-3-3 protein theta

4

20

High-throughput

0.887

High

1049840

1433F
14-3-3 protein eta

3

20

High-throughput

0.861

High

972066

1433E
14-3-3 protein epsilon

2

9

High-throughput

0.820

High

1452680

M3K20
Mitogen-activated protein kinase kinase kinase 20

2

15

Small-scale

0.789

High

730922

1433S
14-3-3 protein sigma

2

20

High-throughput

0.776

High

162050

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

16

Small-scale

0.759

High

287736

KS6A5
Ribosomal protein S6 kinase alpha-5

1

5

High-throughput

0.756

High

1323256

ZN567
Zinc finger protein 567

6

2

High-throughput

0.738

High

1447672

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

4

5

High-throughput

0.698

High

1252725

ZFP2
Zinc finger protein ZFP2

4

4

High-throughput

0.698

High

625670

CSK22
Casein kinase II subunit alpha'

1

9

High-throughput

0.691

High

631517

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.691

High

955677

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

1158577

CDC37
Hsp90 co-chaperone Cdc37

1

5

High-throughput

0.691

High

1446173

PAR6A
Partitioning defective 6 homolog alpha

1

4

High-throughput

0.691

High

1241445

ZFP1
Zinc finger protein 1 homolog

4

5

High-throughput

0.689

High

787461

TGFR1
TGF-beta receptor type-1

1

18

Small-scale

0.665

High

567195

ZNF35
Zinc finger protein 35

3

5

High-throughput

0.665

High

1154181

ITSN1
Intersectin-1

1

8

High-throughput

0.656

High

1006761

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.647

High

1239220

ZN544
Zinc finger protein 544

2

3

High-throughput

0.628

High

1292990

ZN227
Zinc finger protein 227

2

1

High-throughput

0.621

High

170387

AURKA
Aurora kinase A

1

6

High-throughput

0.618

High

401599

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

1157500

PKN1
Serine/threonine-protein kinase N1

1

4

Small-scale

0.618

High

1228523

TENS3
Tensin-3

1

3

High-throughput

0.618

High

1255839

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.618

High

1447354

ANLN
Anillin

1

3

High-throughput

0.618

High

373329

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.611

High

1231112

ZN660
Zinc finger protein 660

2

5

High-throughput

0.606

High

1023983

EM55
55 kDa erythrocyte membrane protein

1

3

High-throughput

0.587

High

853911

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

17

Small-scale

0.575

High

912520

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

17

Small-scale

0.575

High

397087

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

908668

CNN1
Calponin-1

1

1

High-throughput

0.553

High

1056672

ZN33A
Zinc finger protein 33A

1

2

Small-scale

0.552

High

137143

MEIS1
Homeobox protein Meis1

1

3

High-throughput

0.536

High

163476

MEIS2
Homeobox protein Meis2

1

4

High-throughput

0.536

High

694032

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

823864

PBX1
Pre-B-cell leukemia transcription factor 1

1

4

High-throughput

0.536

High

823918

PBX2
Pre-B-cell leukemia transcription factor 2

1

4

High-throughput

0.536

High

823984

PBX3
Pre-B-cell leukemia transcription factor 3

1

4

High-throughput

0.536

High

854351

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

948596

APC15
Anaphase-promoting complex subunit 15

1

1

High-throughput

0.536

High

1117691

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.536

High

1136393

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.536

High

1357127

ZN296
Zinc finger protein 296

1

8

High-throughput

0.536

High

1357991

RN138
E3 ubiquitin-protein ligase RNF138

1

7

High-throughput

0.536

High

1360507

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1368806

EZH1
Histone-lysine N-methyltransferase EZH1

1

4

High-throughput

0.536

High

1421344

BC11B
B-cell lymphoma/leukemia 11B

1

3

High-throughput

0.536

High

1430824

BC11A
BCL11 transcription factor A

1

4

High-throughput

0.536

High

159021

ZN195
Zinc finger protein 195

1

0

High-throughput

0.513

High

329988

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

617746

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

1016386

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1411879

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

1155832

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.508

High

1197724

MIDN
Midnolin

1

1

High-throughput

0.508

High

1238489

ZN746
Zinc finger protein 746

1

1

High-throughput

0.508

High

1385086

ZN775
Zinc finger protein 775

1

3

High-throughput

0.508

High

1431551

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.508

High

1450249

RN19A
E3 ubiquitin-protein ligase RNF19A

1

1

High-throughput

0.508

High

1400040

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

9

High-throughput

0.501

High

1452683

SPCS1
Signal peptidase complex subunit 1

1

2

High-throughput

0.489

High

65985

CCD69
Coiled-coil domain-containing protein 69

1

0

High-throughput

0.486

High

138404

ZN593
Zinc finger protein 593

1

0

High-throughput

0.486

High

983994

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.486

High

1086711

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.486

High

1105181

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.486

High

1123237

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.486

High

132348

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

9

High-throughput

0.479

High

173469

XPO1
Exportin-1

1

3

High-throughput

0.479

High

414735

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

766904

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

1024888

VIGLN
Vigilin

1

2

High-throughput

0.479

High

1045846

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

1138113

TNIP1
TNFAIP3-interacting protein 1

1

6

High-throughput

0.479

High

1367436

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1368154

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1452682

XPO7
Exportin-7

1

3

High-throughput

0.479

High

184077

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

0

High-throughput

0.458

High

954292

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

1335007

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

848579

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.445

High

1258597

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.445

High

756379

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.426

High

379581

IGHM
Immunoglobulin heavy constant mu

1

2

High-throughput

0.417

High

694410

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

1093779

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1452681

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

350310

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025