HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: SYNPO (Q8N3V7)
Synaptopodin
Gene: SYNPO

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	24287595, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0014069 - postsynaptic density
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 929
+	Hs
		594047 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SYNPO_HUMAN (1-929): 1.04e-115: 378: 100.00
+	Hs
		987770 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		SYNPO_HUMAN (1-929): 1.04e-115: 378: 100.00
+	Hs
		215903 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		274251 ITSN2_HUMAN (5-273): 6.53e-36: 141: 19.27		ANR17_HUMAN (165-894): 1.83e-27: 122: 12.17
+	Hs
		463610 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MICA3_HUMAN (231-870): 3.2e-35: 147: 14.50
+	Hs
		987833 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		PRG4_HUMAN (136-925): 9.41e-30: 130: 8.99
+	Hs
		215925 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		319045 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		K0754_HUMAN (620-926): 3.02e-15: 83.1: 12.50
+	Hs
		463316 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		440773 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		MAGL2_HUMAN (551-924): 4.84e-15: 82: 11.50
+	Hs
		439935 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		557066 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		557438 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		CIC_HUMAN (4-916): 4.2e-14: 79.3: 12.01
+	Hs
		590268 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		215893 LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		66953 SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11		L37A2_HUMAN (215-924): 7.11e-11: 68.8: 11.62
+	Hs
		215914 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		215927 SH319_HUMAN (1-57): 7.93e-16: 81.3: 19.30		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		987539 GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31		MAP1A_HUMAN (32-738): 1.29e-10: 67.7: 11.44