HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SYNPO (Q8N3V7)
Synaptopodin
Gene: SYNPO

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	12577067, unassigned3799
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 929
+	Hs
		594047 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNPO_HUMAN (1-929): 1.04e-115: 378: 100.00
+	Hs
		987833 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PRG4_HUMAN (136-925): 9.41e-30: 130: 8.99
+	Hs
		590268 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		215914 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		987539 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MAP1A_HUMAN (32-738): 1.29e-10: 67.7: 11.44
+	Hs
		439935 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		215893 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		274251 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		ANR17_HUMAN (165-894): 1.83e-27: 122: 12.17
+	Hs
		834224 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		CIC_HUMAN (4-916): 4.2e-14: 79.3: 12.01
+	Hs
		362149 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		215903 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		161389 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		KMT2D_HUMAN (395-904): 5.82e-09: 62.3: 12.70
+	Hs
		215927 SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		440773 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MAGL2_HUMAN (551-924): 4.84e-15: 82: 11.50
+	Hs
		557066 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		319045 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		K0754_HUMAN (620-926): 3.02e-15: 83.1: 12.50
+	Hs
		463316 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		MUC1_HUMAN (58-656): 2.2e-15: 83.1: 10.98
+	Hs
		557438 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		CIC_HUMAN (4-916): 4.2e-14: 79.3: 12.01
+	Hs
		215925 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		SYNJ1_HUMAN (31-429): 1.81e-11: 70.4: 13.55
+	Hs
		66953 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		L37A2_HUMAN (215-924): 7.11e-11: 68.8: 11.62