HitPredict

Interactor 1: CLR6 (O59702)
Histone deacetylase clr6 (EC 3.5.1.98) (Cryptic loci regulator 6)
Gene: CLR6

Interactor 2: ATF1 (P52890)
Transcription factor atf1 (Protein sss1) (Transcription factor mts1)
Gene: ATF1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15292231
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 405 Sp			1 566
+	Mm
		140216 HDAC1_MOUSE (2-386): 0: 597: 63.90		JUNB_MOUSE (336-552): 8.79e-29: 119: 17.81
+	Hs
		401956 HDAC1_HUMAN (2-386): 0: 596: 63.64		JUN_HUMAN (220-549): 1.74e-29: 120: 14.91
+	Hs
		556861 HDAC1_HUMAN (2-386): 0: 596: 63.64		CREB1_HUMAN (207-527): 1.93e-27: 114: 15.73
+	Mm
		140232 HDAC1_MOUSE (2-386): 0: 597: 63.90		CREM_MOUSE (207-523): 1.76e-26: 112: 16.52
+	Hs
		974389 HDAC1_HUMAN (2-386): 0: 596: 63.64		CREM_HUMAN (218-523): 4.59e-26: 111: 16.10
+	Hs
		579204 HDAC1_HUMAN (2-386): 0: 596: 63.64		ATF3_HUMAN (391-545): 1.01e-24: 103: 19.23
+	Hs
		402302 HDAC2_HUMAN (2-405): 0: 578: 60.89		JUN_HUMAN (220-549): 1.74e-29: 120: 14.91
+	Hs
		569696 HDAC1_HUMAN (2-386): 0: 596: 63.64		CEBPB_HUMAN (441-543): 2.73e-22: 100: 24.27
+	Mm
		450547 HDAC2_MOUSE (2-405): 0: 576: 60.64		JUNB_MOUSE (336-552): 8.79e-29: 119: 17.81
+	Hs
		556932 HDAC2_HUMAN (2-405): 0: 578: 60.89		CREB1_HUMAN (207-527): 1.93e-27: 114: 15.73
+	Hs
		569923 HDAC2_HUMAN (2-405): 0: 578: 60.89		CEBPB_HUMAN (441-543): 2.73e-22: 100: 24.27
+	Mm
		936396 HDAC2_MOUSE (2-405): 0: 576: 60.64		ATF3_MOUSE (391-545): 1.08e-23: 100: 18.59
+	Hs
		177376 HDAC3_HUMAN (6-403): 0: 540: 57.50		BACH2_HUMAN (137-565): 6.93e-32: 133: 14.69
+	Dm
		576068 HDAC1_DROME (3-405): 0: 585: 59.90		JRA_DROME (437-535): 1.87e-16: 81.9: 24.24
+	Hs
		177168 HDAC3_HUMAN (6-403): 0: 540: 57.50		JUN_HUMAN (220-549): 1.74e-29: 120: 14.91
+	Mm
		404159 Q9JM08_MOUSE (6-403): 0: 536: 57.25		JUN_MOUSE (220-549): 3.89e-30: 122: 14.91
+	Hs
		177140 HDAC3_HUMAN (6-403): 0: 540: 57.50		CREB3_HUMAN (370-553): 3.02e-24: 106: 16.85
+	Hs
		177189 HDAC3_HUMAN (6-403): 0: 540: 57.50		ATF3_HUMAN (391-545): 1.01e-24: 103: 19.23
+	Mm
		1141349 Q9JM08_MOUSE (6-403): 0: 536: 57.25		ATF3_MOUSE (391-545): 1.08e-23: 100: 18.59
+	Sp
		140661 PHD1_SCHPO (4-405): 0: 517: 51.61		PCR1_SCHPO (464-541): 6.4e-16: 77.7: 38.46