HitPredict

Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.956

The method score is based on:

Property Details
Experiments 35271311, 35235311, 34349018, 36652389, 38334954, 35575683, 39358380
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~CH, CH~EFhand_Ca_insen, CH~Spectrin, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin
Common GO terms GO:0001725 - stress fiber
GO:0003713 - transcription coactivator activity
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
and 17 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025