Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4
Interactor 2: ACTN3 (Q08043)
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Gene: ACTN3
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.78 | 1.00 | 0.885 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25416956, 32296183, 35575683, unassigned1304 |
| Identification Methods | two hybrid, cross-linking study, two hybrid prey pooling approach, two hybrid array, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CH~CH, CH~EFhand_Ca_insen, CH~Spectrin, EFhand_Ca_insen~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, Spectrin~Spectrin |
| Common GO terms | GO:0005178 - integrin binding GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030018 - Z disc and 10 others more... |
| Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
