HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RanBP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:1990000 - amyloid fibril formation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 526
+	Hs
		228247 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		227204 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		229193 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		212082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HTSF1_HUMAN (267-372): 6.19e-23: 104: 21.30
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (182-382): 2.39e-13: 74.7: 13.43
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (1-262): 5.36e-11: 67.4: 14.34
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (275-379): 5.23e-10: 63.9: 19.05
+	Hs
		312635 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		312500 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		312578 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		475419 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (228-381): 4.79e-12: 70.5: 16.23
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (286-379): 5.82e-11: 67: 25.53