HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RANG (P43487)
Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)
Gene: RANBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35987950
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 201
+	Hs
		226864 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBP2_HUMAN (4-164): 1.49e-44: 160: 47.83
+	Rn
		88856 PRKN_RAT (1-465): 2.14e-136: 402: 85.16		D4A054_RAT (22-164): 1.64e-42: 153: 53.85
+	Mm
		1322336 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		RBP2_MOUSE (2-160): 2.69e-45: 161: 49.38
+	Hs
		228709 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RANB3_HUMAN (10-186): 4.16e-30: 117: 16.75
+	Hs
		63871 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RGPD3_HUMAN (1-201): 2.17e-46: 165: 34.80