HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: DDX42 (Q86XP3)
ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)
Gene: DDX42

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck GO:0042981 - regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 938
+	Hs
		228251 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		226462 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX5_HUMAN (197-734): 2.1e-147: 452: 35.37
+	Hs
		227864 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX46_HUMAN (8-863): 4.44e-137: 437: 29.71
+	Hs
		133780 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		134115 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		312636 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Hs
		133805 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DDX3X_HUMAN (123-662): 1.87e-134: 420: 29.84
+	Hs
		476139 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DDX17_HUMAN (189-774): 3.85e-154: 473: 34.33
+	Pf
		1181541 Q7KQK2_PLAF7 (1-76): 8.17e-31: 124: 28.95		Q8I416_PLAF7 (119-664): 3.5e-91: 319: 35.79