HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ARMC8 (Q8IUR7)
Armadillo repeat-containing protein 8
Gene: ARMC8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 673
+	Hs
		134807 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMA3_HUMAN (132-580): 2.48e-43: 165: 12.34
+	Hs
		226007 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMA7_HUMAN (152-547): 2.32e-34: 139: 13.22
+	Hs
		168603 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMA6_HUMAN (389-673): 1.01e-32: 134: 17.30
+	Hs
		226926 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMA1_HUMAN (14-276): 2.01e-28: 121: 15.47
+	Hs
		226927 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMA5_HUMAN (152-547): 6.76e-28: 120: 13.22
+	Hs
		131348 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		IMA4_HUMAN (30-355): 2.8e-24: 109: 12.63
+	Dm
		284385 ARI2_DROME (228-464): 7.29e-69: 229: 20.92		Q9V455_DROME (396-673): 5.7e-32: 132: 16.73
+	Hs
		853500 AKIB1_HUMAN (238-456): 1.26e-60: 215: 21.55		IMA1_HUMAN (14-276): 2.01e-28: 121: 15.47
+	At
		285378 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IMPA4_ARATH (145-580): 8.32e-42: 161: 13.78
+	At
		97780 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IMPA2_ARATH (145-580): 9.53e-38: 149: 13.36
+	At
		1091951 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		IMPA1_ARATH (12-220): 1.73e-25: 113: 13.21