Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN
Interactor 2: KLH18 (O94889)
Kelch-like protein 18
Gene: KLHL18
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.44 | 1.00 | 0.665 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32814053 |
| Identification Methods | two hybrid array, two hybrid pooling approach, validated two hybrid |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Kelch_1~ubiquitin |
| Common GO terms | GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process |
| Homologous interactions | 14 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
