HitPredict

Interactor 1: TLR5 (O60602)
Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
Gene: TLR5

Interactor 2: CNPY3 (Q9BT09)
Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat-domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat-containing gene 5 protein)
Gene: CNPY3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045087 - innate immune response
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 858 Hs			1 278
+	Hs
		777250 ALS_HUMAN (24-626): 1.78e-76: 262: 24.73		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		1412989 TLR9_HUMAN (31-645): 6.34e-42: 168: 17.19		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		1412990 TLR8_HUMAN (274-609): 5.92e-21: 101: 19.23		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		126333 TLR4_HUMAN (253-719): 2.21e-20: 98.7: 16.46		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		1412972 TLR10_HUMAN (2-472): 3.51e-19: 94.9: 14.70		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		820573 GPV_HUMAN (290-624): 8.07e-19: 93.2: 28.81		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		212907 LRRT2_HUMAN (270-536): 1.4e-18: 92: 30.82		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		1148234 TLR1_HUMAN (2-489): 2.54e-16: 85.7: 13.33		CNPY3_HUMAN (1-278): 9.7e-149: 419: 100.00
+	Hs
		820563 GPV_HUMAN (290-624): 8.07e-19: 93.2: 28.81		CNPY4_HUMAN (17-215): 2.15e-110: 320: 48.00
+	Hs
		212904 LRRT2_HUMAN (270-536): 1.4e-18: 92: 30.82		CNPY4_HUMAN (17-215): 2.15e-110: 320: 48.00
+	Mm
		1297239 TLR4_MOUSE (212-579): 7.8e-16: 84.1: 16.54		CNPY4_MOUSE (10-215): 4.24e-111: 322: 47.34