HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: PGS2 (P07585)
Decorin (Bone proteoglycan II) (PG-S2) (PG40)
Gene: DCN

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22087031
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_1~LRR_8, LRRNT~LRR_1, LRR_8~LRR_8, LRRNT~LRR_8, LRRCT~LRR_8, LRRCT~LRRNT
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 784 Hs			1 359
+	Hs
		252369 TLR2_HUMAN (1-784): 5.23e-128: 402: 100.00		LGR4_HUMAN (166-359): 4.81e-29: 120: 20.71
+	Hs
		126317 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		TRIL_HUMAN (40-358): 1.39e-59: 207: 23.81
+	Hs
		252322 TLR2_HUMAN (1-784): 5.23e-128: 402: 100.00		PGS1_HUMAN (2-173): 9.68e-16: 79.5: 23.24
+	Hs
		191222 TLR3_HUMAN (1-784): 1.44e-77: 270: 18.18		TRIL_HUMAN (40-358): 1.39e-59: 207: 23.81
+	Hs
		126282 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		PGS2_HUMAN (130-359): 7.56e-35: 132: 21.12
+	Hs
		126293 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		PGS1_HUMAN (2-173): 9.68e-16: 79.5: 23.24
+	At
		88929 Y4361_ARATH (1-611): 1.53e-70: 253: 14.86		ERL1_ARATH (145-359): 1.94e-28: 118: 18.39
+	At
		88652 Y4361_ARATH (1-611): 1.53e-70: 253: 14.86		GSO1_ARATH (2-225): 1.81e-22: 101: 16.88
+	At
		1192470 EMS1_ARATH (1-611): 3.91e-68: 246: 14.19		ERECT_ARATH (3-204): 3.07e-19: 91: 14.55
+	At
		235840 EMS1_ARATH (1-611): 3.91e-68: 246: 14.19		BAME1_ARATH (1-148): 1.8e-15: 79.9: 15.89
+	At
		88933 Y4361_ARATH (1-611): 1.53e-70: 253: 14.86		PXC3_ARATH (2-147): 3.54e-11: 66.4: 14.00
+	At
		1442339 Y1571_ARATH (101-679): 3.89e-61: 225: 14.75		BRL2_ARATH (2-222): 5.27e-18: 87.6: 15.68
+	At
		1441447 EMS1_ARATH (1-611): 3.91e-68: 246: 14.19		RGI1_ARATH (1-161): 3.01e-09: 60.6: 13.86
+	At
		1250995 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		ERL2_ARATH (141-359): 4.57e-29: 120: 17.94
+	Zm
		19535 A0A1D6HD42_MAIZE (152-711): 7.99e-47: 182: 14.71		A0A1D6HD42_MAIZE (222-359): 1.16e-22: 101: 20.14
+	At
		89570 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		ERL1_ARATH (145-359): 1.94e-28: 118: 18.39
+	Zm
		117526 K7V4X2_MAIZE (53-543): 3.74e-47: 183: 15.03		K7V4X2_MAIZE (3-194): 8.37e-16: 81.1: 16.24
+	At
		103567 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		RGI4_ARATH (3-197): 1.18e-19: 92.6: 16.04
+	At
		1192463 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		ERECT_ARATH (3-204): 3.07e-19: 91: 14.55
+	At
		235822 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		BAME1_ARATH (1-148): 1.8e-15: 79.9: 15.89