Protein: PGS1
Biglycan (Bone/cartilage proteoglycan I) (PG-S1)

Gene: PGS1, BGN
Organism: Homo sapiens
Interactions: 28
UniProt ID: P21810

Gene Ontology (top 5):
GO:0001974 - blood vessel remodeling
GO:0005201 - extracellular matrix structural constituent
GO:0005539 - glycosaminoglycan binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126293

TLR4
Toll-like receptor 4

1

20

Small-scale

0.647

High

252322

TLR2
Toll-like receptor 2

1

20

Small-scale

0.647

High

376706

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

4

Small-scale

0.647

High

464417

TSP1
Thrombospondin-1

1

20

Small-scale

0.647

High

551759

CO6A1

1

3

Small-scale

0.647

High

421500

A4
Amyloid-beta precursor protein

2

6

Small-scale

0.602

High

641296

CMA1
Chymase

1

5

Small-scale

0.575

High

377963

TNFA
Tumor necrosis factor

1

2

Small-scale

0.561

High

641302

SGCA
Alpha-sarcoglycan

1

1

Small-scale

0.561

High

384111

CO1A1
Collagen alpha-1(I) chain

1

3

Small-scale

0.501

High

384302

CO4A1

1

3

Small-scale

0.501

High

584612

ELN
Elastin

1

6

Small-scale

0.501

High

641297

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

5

Small-scale

0.501

High

641300

PCOC1
Procollagen C-endopeptidase enhancer 1

1

5

Small-scale

0.501

High

641308

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.493

High

641307

LZTS2
Leucine zipper putative tumor suppressor 2

1

8

High-throughput

0.488

High

403126

APOB
Apolipoprotein B-100

1

0

Small-scale

0.480

High

641298

MFAP2
Microfibrillar-associated protein 2

1

0

Small-scale

0.480

High

136829

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

11

High-throughput

0.479

High

217826

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

641303

PKHG4
Puratrophin-1

1

1

High-throughput

0.470

High

105333

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

641306

FBXW7
F-box/WD repeat-containing protein 7

1

1

Small-scale

0.437

High

641305

JPH3
Junctophilin-3

2

0

Small-scale

0.318

High

641309

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.268

Low

641301

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

641299

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.249

Low

641304

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025