HitPredict

Interactor 1: TLR2 (O60603)
Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
Gene: TLR2

Interactor 2: PGS1 (P21810)
Biglycan (Bone/cartilage proteoglycan I) (PG-S1)
Gene: BGN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24480070
Identification Methods	microscale thermophoresis
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	LRR_1~LRR_8, LRRNT~LRR_1, LRR_8~LRR_8, LRRNT~LRR_8, LRRCT~LRR_8, LRRCT~LRRNT
Common GO terms	GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 784 Hs			1 368
+	Hs
		252310 TLR2_HUMAN (1-784): 5.23e-128: 402: 100.00		PGS2_HUMAN (6-367): 1.95e-71: 228: 53.72
+	Hs
		126293 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		PGS1_HUMAN (1-368): 2.79e-82: 257: 100.00
+	Hs
		252369 TLR2_HUMAN (1-784): 5.23e-128: 402: 100.00		LGR4_HUMAN (28-310): 8.46e-34: 134: 22.39
+	Hs
		126282 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		PGS2_HUMAN (6-367): 1.95e-71: 228: 53.72
+	At
		88929 Y4361_ARATH (1-611): 1.53e-70: 253: 14.86		ERL1_ARATH (3-317): 3.45e-43: 161: 14.41
+	At
		88933 Y4361_ARATH (1-611): 1.53e-70: 253: 14.86		PXC3_ARATH (14-291): 5.52e-41: 155: 15.97
+	Hs
		126317 TLR4_HUMAN (2-782): 9.11e-87: 294: 22.87		TRIL_HUMAN (79-208): 5.4e-19: 90.7: 22.06
+	Zm
		19535 A0A1D6HD42_MAIZE (152-711): 7.99e-47: 182: 14.71		A0A1D6HD42_MAIZE (33-367): 8.15e-53: 190: 20.63
+	At
		1442339 Y1571_ARATH (101-679): 3.89e-61: 225: 14.75		BRL2_ARATH (6-302): 1.09e-36: 143: 14.46
+	Hs
		191222 TLR3_HUMAN (1-784): 1.44e-77: 270: 18.18		TRIL_HUMAN (79-208): 5.4e-19: 90.7: 22.06
+	At
		1250995 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		ERL2_ARATH (3-356): 8.77e-47: 172: 15.72
+	At
		1192470 EMS1_ARATH (1-611): 3.91e-68: 246: 14.19		ERECT_ARATH (3-194): 1.48e-17: 86.4: 13.68
+	At
		89570 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		ERL1_ARATH (3-317): 3.45e-43: 161: 14.41
+	At
		103567 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		RGI4_ARATH (40-367): 1.07e-42: 160: 18.86
+	At
		1441447 EMS1_ARATH (1-611): 3.91e-68: 246: 14.19		RGI1_ARATH (3-170): 1.05e-13: 74.5: 15.08
+	At
		199524 Y5639_ARATH (184-711): 1.75e-37: 153: 12.36		PXC3_ARATH (14-291): 5.52e-41: 155: 15.97
+	Zm
		117526 K7V4X2_MAIZE (53-543): 3.74e-47: 183: 15.03		K7V4X2_MAIZE (2-202): 3.12e-15: 79.1: 16.67
+	At
		1192463 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		ERECT_ARATH (3-194): 1.48e-17: 86.4: 13.68
+	At
		1426160 FLS2_ARATH (1-278): 2.33e-41: 165: 13.33		IRK_ARATH (3-170): 2.31e-15: 79.5: 16.85
+	At
		89606 HSL2_ARATH (152-692): 1.44e-37: 153: 11.25		ERECT_ARATH (3-194): 1.48e-17: 86.4: 13.68