HitPredict

Interactor 1: NPHP4 (O75161)
Nephrocystin-4 (Nephroretinin)
Gene: NPHP4

Interactor 2: RPGR1 (Q96KN7)
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)
Gene: RPGRIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	25018096, 26638075, 16339905, 21224891
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0120206 - photoreceptor distal connecting cilium
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1426 Hs			1 1286
+	Hs
		256892 NPHP4_HUMAN (1-1426): 0: 2443: 100.00		FTM_HUMAN (1-1284): 0: 717: 29.80
+	Mm
		886790 NPHP4_MOUSE (1-1426): 0: 2449: 78.13		FTM_MOUSE (1-1284): 0: 694: 29.93
+	Mm
		886742 NPHP4_MOUSE (1-1426): 0: 2449: 78.13		MYH10_MOUSE (8-609): 1.27e-20: 101: 11.49
+	Mm
		886800 NPHP4_MOUSE (1-1426): 0: 2449: 78.13		MYH9_MOUSE (13-664): 2.89e-20: 99: 10.63
+	Mm
		93547 NPHP4_MOUSE (1-1426): 0: 2449: 78.13		DESP_MOUSE (57-812): 1.11e-16: 88.6: 8.05
+	Bt
		90469 E1BJB5_BOVIN (46-1426): 0: 2290: 77.71		RPGR1_BOVIN (79-400): 1.02e-12: 75.2: 10.00
+	Ce
		105365 G5ECP0_CAEEL (1-1426): 0: 999: 22.64		FTM_CAEEL (45-1101): 1.19e-90: 322: 15.84