HitPredict

Interactor 1: TRI13 (O60858)
E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13)
Gene: TRIM13

Interactor 2: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	37205848
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005737 - cytoplasm GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 407 Hs			1 152
+	Hs
		258270 TRI13_HUMAN (1-407): 1.13e-132: 388: 100.00		UB2D2_HUMAN (4-149): 6.82e-80: 234: 46.58
+	Hs
		258263 TRI13_HUMAN (1-407): 1.13e-132: 388: 100.00		UB2D3_HUMAN (4-149): 9.69e-79: 231: 45.89
+	Hs
		258256 TRI13_HUMAN (1-407): 1.13e-132: 388: 100.00		UB2E1_HUMAN (1-149): 1.32e-73: 219: 45.64
+	Hs
		623204 RO52_HUMAN (1-321): 2.81e-71: 233: 15.74		UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21
+	Hs
		623249 RO52_HUMAN (1-321): 2.81e-71: 233: 15.74		UB2D2_HUMAN (4-149): 6.82e-80: 234: 46.58
+	Hs
		623219 RO52_HUMAN (1-321): 2.81e-71: 233: 15.74		UB2D3_HUMAN (4-149): 9.69e-79: 231: 45.89
+	Hs
		1439327 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2D4_HUMAN (4-149): 3.69e-81: 237: 45.89
+	Hs
		906743 TRI11_HUMAN (3-315): 7e-68: 224: 18.47		UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21
+	Hs
		906790 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2D1_HUMAN (4-149): 2.33e-80: 235: 45.21
+	Mm
		982385 TRI17_MOUSE (2-314): 3.58e-68: 225: 18.10		UB2D2_MOUSE (4-149): 6.82e-80: 234: 46.58
+	Hs
		982330 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2D2_HUMAN (4-149): 6.82e-80: 234: 46.58
+	Hs
		957138 TRI58_HUMAN (2-319): 3.88e-68: 225: 16.61		UB2D3_HUMAN (4-149): 9.69e-79: 231: 45.89
+	Mm
		957264 TRI17_MOUSE (2-314): 3.58e-68: 225: 18.10		UB2D3_MOUSE (4-149): 9.69e-79: 231: 45.89
+	Hs
		957208 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2D3_HUMAN (4-149): 9.69e-79: 231: 45.89
+	Hs
		623207 RO52_HUMAN (1-321): 2.81e-71: 233: 15.74		UB2E1_HUMAN (1-149): 1.32e-73: 219: 45.64
+	Hs
		623221 RO52_HUMAN (1-321): 2.81e-71: 233: 15.74		UBE2N_HUMAN (1-152): 1.64e-73: 218: 100.00
+	Hs
		1397295 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2E2_HUMAN (1-149): 9.47e-76: 225: 44.97
+	Hs
		1381205 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2E3_HUMAN (1-149): 2.32e-75: 224: 44.97
+	Hs
		909393 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UB2E1_HUMAN (1-149): 1.32e-73: 219: 45.64
+	Hs
		957847 TRI39_HUMAN (1-315): 2.27e-67: 224: 17.10		UBE2N_HUMAN (1-152): 1.64e-73: 218: 100.00