HitPredict

Interactor 1: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	36931259, 14676191, 16959763
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 752
+	Hs
		909916 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK4_HUMAN (1-752): 0: 733: 100.00
+	Mm
		910308 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK4_MOUSE (1-752): 0: 731: 97.61
+	Hs
		647862 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Mm
		910231 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK3_MOUSE (1-752): 0: 700: 58.69
+	Xl
		223344 O57468_XENLA (1-244): 9.73e-141: 396: 62.71		Q804T2_XENLA (1-752): 0: 692: 59.95
+	Xl
		223345 O57468_XENLA (1-244): 9.73e-141: 396: 62.71		Q8QGV3_XENLA (1-752): 0: 650: 49.75
+	Mm
		910234 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK2_MOUSE (2-752): 0: 641: 49.69
+	Hs
		909730 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		910106 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MARK1_HUMAN (1-752): 0: 632: 51.06
+	Mm
		910318 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		MARK1_MOUSE (1-752): 0: 631: 51.06
+	Hs
		909567 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		MELK_HUMAN (59-752): 1.3e-176: 522: 26.44
+	Hs
		910071 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SNRK_HUMAN (59-603): 9.4e-160: 483: 32.55
+	Mm
		910272 1433E_MOUSE (1-244): 1.37e-141: 398: 62.71		BRSK2_MOUSE (55-504): 8.46e-147: 448: 36.66
+	Hs
		909786 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		BRSK2_HUMAN (55-504): 2.77e-146: 447: 36.66
+	Hs
		883214 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	At
		1280891 14337_ARATH (2-244): 2.9e-141: 398: 59.18		CIPKC_ARATH (45-372): 1.2e-138: 419: 37.35
+	At
		788672 14333_ARATH (1-244): 1.01e-141: 398: 61.38		CIPKC_ARATH (45-372): 1.2e-138: 419: 37.35
+	At
		965360 14332_ARATH (4-244): 8.72e-141: 396: 60.91		CIPKC_ARATH (45-372): 1.2e-138: 419: 37.35
+	Hs
		910187 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SIK3_HUMAN (56-367): 1.81e-109: 363: 59.32
+	Hs
		910013 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SIK2_HUMAN (56-367): 5.39e-104: 341: 55.17