HitPredict

Interactor 1: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Interactor 2: TWST1 (Q15672)
Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)
Gene: TWIST1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	31311807, 24525235
Identification Methods	affinity chromatography technology, nuclear magnetic resonance, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1362 Hs			1 202
+	Hs
		1151968 KAT2B_HUMAN (327-456): 5.64e-22: 105: 26.92		TWST1_HUMAN (1-202): 3.44e-49: 160: 100.00
+	Mm
		107162 F8VQD1_MOUSE (189-501): 1.14e-17: 91.7: 15.06		TWST1_MOUSE (1-202): 1.28e-47: 156: 92.72
+	Dm
		1489640 Q9W1S2_DROME (341-458): 1.23e-36: 141: 37.29		AMOS_DROME (16-166): 2.17e-25: 99.3: 25.00
+	Mm
		107147 F8VQ93_MOUSE (26-587): 4.83e-15: 83.2: 13.54		TWST1_MOUSE (1-202): 1.28e-47: 156: 92.72
+	Mm
		644310 Q3UE68_MOUSE (170-669): 3e-31: 135: 14.23		TAL1_MOUSE (104-169): 5.94e-21: 90.3: 47.76
+	Hs
		342100 BRD1_HUMAN (192-769): 1.38e-30: 133: 13.50		TAL1_HUMAN (104-176): 3.44e-21: 90.7: 43.24
+	Hs
		587510 KAT2B_HUMAN (327-456): 5.64e-22: 105: 26.92		TFE2_HUMAN (7-184): 5.9e-29: 114: 22.95
+	Mm
		59399 CHD7_MOUSE (445-951): 8.36e-09: 62.8: 8.04		TWST1_MOUSE (1-202): 1.28e-47: 156: 92.72
+	Hs
		587509 KAT2A_HUMAN (327-456): 1.77e-20: 100: 26.15		TFE2_HUMAN (7-184): 5.9e-29: 114: 22.95
+	Hs
		1037901 BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56		HEN1_HUMAN (53-164): 3.2e-20: 84.2: 36.28
+	Hs
		1273926 KAT2B_HUMAN (327-456): 5.64e-22: 105: 26.92		PTF1A_HUMAN (57-166): 5.79e-25: 101: 40.17
+	Mm
		518527 KAT2B_MOUSE (327-456): 1.05e-21: 104: 26.92		MYOD1_MOUSE (69-191): 2.33e-25: 101: 21.90
+	Hs
		1273925 KAT2A_HUMAN (327-456): 1.77e-20: 100: 26.15		PTF1A_HUMAN (57-166): 5.79e-25: 101: 40.17
+	Hs
		605213 KAT2B_HUMAN (327-456): 5.64e-22: 105: 26.92		TAL1_HUMAN (104-176): 3.44e-21: 90.7: 43.24
+	Mm
		644445 KAT2B_MOUSE (327-456): 1.05e-21: 104: 26.92		TAL1_MOUSE (104-169): 5.94e-21: 90.3: 47.76
+	Hs
		1037860 BPTF_HUMAN (67-161): 9.91e-11: 68.9: 41.05		HEN1_HUMAN (53-164): 3.2e-20: 84.2: 36.28