Protein: HEN1
Helix-loop-helix protein 1 (HEN-1) (Class A basic helix-loop-helix protein 35) (bHLHa35) (Nescient helix loop helix 1) (NSCL-1)

Gene: HEN1, NHLH1
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q02575

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587450

TFE2
Transcription factor E2-alpha

2

20

Small-scale

0.793

High

587056

ITF2
Transcription factor 4

1

20

High-throughput

0.691

High

1037885

HTF4
Transcription factor 12

1

20

High-throughput

0.691

High

1037868

CENPP
Centromere protein P

3

1

High-throughput

0.654

High

681791

RBTN2
Rhombotin-2

1

16

Small-scale

0.621

High

1037870

MGAP
MAX gene-associated protein

1

3

High-throughput

0.618

High

586274

ZEP1
Zinc finger protein 40

2

7

High-throughput

0.586

High

1037861

NFIA
Nuclear factor 1 A-type

1

9

High-throughput

0.561

High

142948

NFIB
Nuclear factor 1 B-type

1

9

High-throughput

0.501

High

1037859

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.500

High

1037884

HEXI2
Protein HEXIM2

1

3

High-throughput

0.500

High

1037910

PDIP2
Polymerase delta-interacting protein 2

1

1

High-throughput

0.500

High

541015

PIM1
Serine/threonine-protein kinase pim-1

1

3

High-throughput

0.481

High

301880

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.479

High

135178

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.479

High

161449

KMT2D
Histone-lysine N-methyltransferase 2D

1

11

High-throughput

0.479

High

194549

KDM6A
Lysine-specific demethylase 6A

1

5

High-throughput

0.479

High

320660

UBXN7
UBX domain-containing protein 7

1

2

High-throughput

0.479

High

344925

WIZ
Protein Wiz

1

7

High-throughput

0.479

High

790026

ZEB1
Zinc finger E-box-binding homeobox 1

1

6

High-throughput

0.479

High

854003

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.479

High

855049

NOP2
28S rRNA

1

1

High-throughput

0.479

High

886459

CTCF
Transcriptional repressor CTCF

1

5

High-throughput

0.479

High

892006

TAF6
Transcription initiation factor TFIID subunit 6

1

1

High-throughput

0.479

High

903134

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

14

High-throughput

0.479

High

926336

BLM
RecQ-like DNA helicase BLM

1

2

High-throughput

0.479

High

1017403

FOXK1
Forkhead box protein K1

1

2

High-throughput

0.479

High

1029661

FOXK2
Forkhead box protein K2

1

2

High-throughput

0.479

High

1037858

KMT2A
Histone-lysine N-methyltransferase 2A

1

5

High-throughput

0.479

High

1037860

BPTF
Nucleosome-remodeling factor subunit BPTF

1

18

High-throughput

0.479

High

1037862

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.479

High

1037863

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.479

High

1037865

ZN260
Zinc finger protein 260

1

3

High-throughput

0.479

High

1037866

ARI4B
AT-rich interactive domain-containing protein 4B

1

8

High-throughput

0.479

High

1037869

UBN2
Ubinuclein-2

1

8

High-throughput

0.479

High

1037874

PHF10
PHD finger protein 10

1

10

High-throughput

0.479

High

1037875

REQU
Zinc finger protein ubi-d4

1

15

High-throughput

0.479

High

1037876

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1037877

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.479

High

1037878

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

6

High-throughput

0.479

High

1037880

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

2

High-throughput

0.479

High

1037881

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

6

High-throughput

0.479

High

1037883

ZN512
Zinc finger protein 512

1

4

High-throughput

0.479

High

1037889

ARI3A
AT-rich interactive domain-containing protein 3A

1

5

High-throughput

0.479

High

1037892

PCGF6
Polycomb group RING finger protein 6

1

2

High-throughput

0.479

High

1037893

GTPB4
GTP-binding protein 4

1

2

High-throughput

0.479

High

1037894

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1037898

ZN644
Zinc finger protein 644

1

6

High-throughput

0.479

High

1037900

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

4

High-throughput

0.479

High

1037901

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.479

High

1037904

DDX56
Probable ATP-dependent RNA helicase DDX56

1

2

High-throughput

0.479

High

1037907

TRPS1
Zinc finger transcription factor Trps1

1

9

High-throughput

0.479

High

1037909

ZBT21
Zinc finger and BTB domain-containing protein 21

1

3

High-throughput

0.479

High

182976

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.458

High

961701

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

1037867

CDCA2
Cell division cycle-associated protein 2

1

0

High-throughput

0.458

High

1037886

NP1L4
Nucleosome assembly protein 1-like 4

1

0

High-throughput

0.458

High

1037895

REXO4
RNA exonuclease 4

1

0

High-throughput

0.458

High

1037899

DDX31
ATP-dependent DNA helicase DDX31

1

0

High-throughput

0.458

High

1037902

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1037897

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.457

High

140877

NOP56
Nucleolar protein 56

1

1

High-throughput

0.437

High

288634

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.437

High

290534

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.437

High

1037864

BMS1
Ribosome biogenesis protein BMS1 homolog

1

1

High-throughput

0.437

High

1037871

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

5

High-throughput

0.437

High

1037872

KRI1
Protein KRI1 homolog

1

1

High-throughput

0.437

High

1037882

EP400
E1A-binding protein p400

1

15

High-throughput

0.437

High

1037888

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.437

High

1037896

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

1037903

RBM28
RNA-binding protein 28

1

1

High-throughput

0.437

High

1037911

NOP16
Nucleolar protein 16

1

1

High-throughput

0.437

High

1037887

TCPH
T-complex protein 1 subunit eta

2

0

High-throughput

0.316

High

1037873

IN80E
INO80 complex subunit E

1

0

High-throughput

0.251

Low

1037908

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.251

Low

96664

E9PAV9
G patch domain-containing protein 4

1

0

High-throughput

0.249

Low

643459

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

841341

RBM34
RNA-binding protein 34

1

0

High-throughput

0.249

Low

1037879

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.249

Low

1037890

CHOLN
Protein cholesin

1

0

High-throughput

0.249

Low

1037891

LLPH
Protein LLP homolog

1

0

High-throughput

0.249

Low

1037905

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.249

Low

1037906

CFDP1
Craniofacial development protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025