Protein: TWST1
Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)

Gene: TWST1, TWIST1
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q15672

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587088

ITF2
Transcription factor 4

5

20

Small-scale

0.930

High

587477

TFE2
Transcription factor E2-alpha

5

20

Small-scale

0.928

High

634846

HXA5
Homeobox protein Hox-A5

1

16

Small-scale

0.740

High

413901

P53
Cellular tumor antigen p53

3

2

Small-scale

0.697

High

959586

MAX
Protein max

1

11

High-throughput

0.691

High

1151973

HES6
Transcription cofactor HES-6

1

19

Small-scale

0.691

High

1151975

HTF4
Transcription factor 12

1

20

High-throughput

0.691

High

1151982

FBW1A
F-box/WD repeat-containing protein 1A

4

2

Small-scale

0.676

High

1045327

TF65
Transcription factor p65

3

8

Small-scale

0.656

High

1151968

KAT2B
Histone acetyltransferase KAT2B

2

11

Small-scale

0.639

High

675515

TYY1
Transcriptional repressor protein YY1

2

9

Small-scale

0.636

High

260001

BRD4
Bromodomain-containing protein 4

2

16

Small-scale

0.628

High

1067369

EP300
Histone acetyltransferase p300

2

19

Small-scale

0.624

High

1151958

TWST1
Twist-related protein 1

1

19

Small-scale

0.618

High

1151966

TWST2
Twist-related protein 2

1

20

Small-scale

0.618

High

979720

H4
Histone H4

2

2

Small-scale

0.612

High

1086162

CETN1
Centrin-1

2

0

High-throughput

0.602

High

1151976

KMT5A
N-lysine methyltransferase KMT5A

1

13

Small-scale

0.597

High

827796

STAT3
Signal transducer and activator of transcription 3

2

2

High-throughput

0.594

High

302535

RNF8
E3 ubiquitin-protein ligase RNF8

2

6

Small-scale

0.584

High

1151970

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

4

Small-scale

0.578

High

316866

MTA2
Metastasis-associated protein MTA2

1

5

Small-scale

0.561

High

504738

FBSP1
F-box/SPRY domain-containing protein 1

1

3

Small-scale

0.561

High

590284

MUC1
Mucin-1

1

4

Small-scale

0.561

High

1099928

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.561

High

1151959

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.561

High

1151974

TRIB3
Tribbles homolog 3

1

2

Small-scale

0.561

High

1151980

UBP18
Ubl carboxyl-terminal hydrolase 18

1

8

Small-scale

0.561

High

1151978

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

Small-scale

0.554

High

227572

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.537

High

994232

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.536

High

1151963

BRAP
BRCA1-associated protein

1

3

Small-scale

0.536

High

578299

ETS2
Protein C-ets-2

1

16

Small-scale

0.534

High

188616

TYY2
Transcription factor YY2

1

7

High-throughput

0.527

High

249344

ZIC3
Zinc finger protein ZIC 3

1

5

High-throughput

0.527

High

832726

BCL6
B-cell lymphoma 6 protein

1

4

High-throughput

0.527

High

843586

HD
Huntingtin

1

2

High-throughput

0.515

High

1151965

NEIL3
Endonuclease 8-like 3

1

0

High-throughput

0.505

High

72367

IMA8
Importin subunit alpha-8

1

2

Small-scale

0.501

High

167903

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.501

High

179049

IMA6
Importin subunit alpha-6

1

2

Small-scale

0.501

High

951690

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

1132715

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

Small-scale

0.501

High

188286

HDAC3
Histone deacetylase 3

1

8

Small-scale

0.479

High

626243

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

11

Small-scale

0.479

High

714149

PML
Protein PML

1

7

Small-scale

0.479

High

764779

CTNB1
Catenin beta-1

1

2

Small-scale

0.479

High

872364

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

931524

RD23A
UV excision repair protein RAD23 homolog A

1

1

Small-scale

0.479

High

964969

WDR5
WD repeat-containing protein 5

1

1

Small-scale

0.479

High

1094558

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

Small-scale

0.479

High

1101820

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.479

High

1109756

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.479

High

1115207

CUL4B
Cullin-4B

1

5

Small-scale

0.479

High

1151960

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

6

Small-scale

0.479

High

1151961

PAQR3
Progestin and adipoQ receptor family member 3

1

2

Small-scale

0.479

High

1151962

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

5

Small-scale

0.479

High

1151967

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.479

High

1151977

DNM3B
DNA

1

1

Small-scale

0.479

High

221855

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.458

High

914083

HXK2
Hexokinase-2

1

0

Small-scale

0.458

High

986446

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

Small-scale

0.458

High

1058034

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

Small-scale

0.457

High

897836

CDK9
Cyclin-dependent kinase 9

1

3

Small-scale

0.445

High

1151969

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.445

High

533669

CLUS
Clusterin

1

0

Small-scale

0.438

High

1151972

ESPB1
Epididymal sperm-binding protein 1

1

2

Small-scale

0.437

High

1151979

CBLC
E3 ubiquitin-protein ligase CBL-C

1

2

Small-scale

0.437

High

1151981

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

Small-scale

0.437

High

1151983

RBGP1
Rab GTPase-activating protein 1

1

1

High-throughput

0.437

High

1151964

FXL14
F-box/LRR-repeat protein 14

1

0

Small-scale

0.249

Low

1151971

ARRD3
Arrestin domain-containing protein 3

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025