HitPredict

Interactor 1: MK38B (O61443)
Mitogen-activated protein kinase p38b (MAP kinase p38b) (MAPK p38b) (EC 2.7.11.24)
Gene: p38b

Interactor 2: MAPK2 (P49071)
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (EC 2.7.11.1)
Gene: MAPk-Ak2

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.910

The method score is based on:

Property Details
Experiments 22801366, 21829386, 14605208, 22036573, 38944040
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0009651 - response to salt stress
GO:0035556 - intracellular signal transduction
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 365
Dm

1 359
+ Dm
+ At
+ At
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+ At
+ At
+ At
+ At
+ Mm
+ Hs
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+ Hs
+ At
+ Hs
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+ Rn
+ Hs
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+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025