Protein: MAPK5
MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK)

Gene: MAPK5, MAPKAPK5
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q8IW41

Gene Ontology (top 5):
GO:0002039 - p53 binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1161136

MK06
Mitogen-activated protein kinase 6

11

20

High-throughput

0.983

High

724694

MK04
Mitogen-activated protein kinase 4

4

20

Small-scale

0.905

High

1158132

MK14
Mitogen-activated protein kinase 14

3

20

Small-scale

0.845

High

879734

MAPK2
MAP kinase-activated protein kinase 2

1

16

Small-scale

0.713

High

1006523

SRPK2
SRSF protein kinase 2

1

19

High-throughput

0.710

High

1309540

SRPK1
SRSF protein kinase 1

1

15

High-throughput

0.710

High

1309544

ZN576
Zinc finger protein 576

1

1

High-throughput

0.698

High

415698

HSPB1
Heat shock protein beta-1

4

8

Small-scale

0.694

High

1309539

TRIB3
Tribbles homolog 3

1

19

High-throughput

0.691

High

1153061

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

11

High-throughput

0.656

High

1309543

ZN577
Zinc finger protein 577

1

0

High-throughput

0.656

High

1309534

MAPK5
MAP kinase-activated protein kinase 5

1

16

Small-scale

0.647

High

1309546

ZN282
Zinc finger protein 282

1

0

High-throughput

0.622

High

242206

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.618

High

885830

KC1E
Casein kinase I isoform epsilon

1

12

Small-scale

0.618

High

908139

KS6A3
Ribosomal protein S6 kinase alpha-3

1

17

High-throughput

0.618

High

1309535

STK40
Serine/threonine-protein kinase 40

1

18

Small-scale

0.618

High

862279

YAP1
Transcriptional coactivator YAP1

2

10

Small-scale

0.595

High

184643

MK13
Mitogen-activated protein kinase 13

1

20

Small-scale

0.575

High

923361

MK12
Mitogen-activated protein kinase 12

1

20

Small-scale

0.575

High

1153372

MK11
Mitogen-activated protein kinase 11

1

20

Small-scale

0.575

High

1309541

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.569

High

414158

P53
Cellular tumor antigen p53

1

3

Small-scale

0.550

High

1309537

NEUL4
Neuralized-like protein 4

2

1

High-throughput

0.549

High

1142475

RAGE
Advanced glycosylation end product-specific receptor

1

5

Small-scale

0.543

High

342946

HERC2
E3 ubiquitin-protein ligase HERC2

1

7

High-throughput

0.536

High

1200130

BOREA
Borealin

1

0

High-throughput

0.518

High

651829

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.513

High

1309542

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

0

High-throughput

0.513

High

481328

HMGB1
High mobility group protein B1

1

1

Small-scale

0.508

High

1156304

HSPB2
Heat shock protein beta-2

1

8

Small-scale

0.501

High

532741

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

686253

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.486

High

791514

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

684012

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

3

High-throughput

0.479

High

691218

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

966580

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

970741

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

990463

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1246132

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

2

High-throughput

0.479

High

1276451

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1309536

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.479

High

1309538

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

1309547

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1309545

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.458

High

530050

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

1293254

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025