Protein: MK11
Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)

Gene: MK11, MAPK11
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q15759

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1153369

MAPK3
MAP kinase-activated protein kinase 3

7

20

High-throughput

0.969

High

879722

MAPK2
MAP kinase-activated protein kinase 2

5

20

Small-scale

0.925

High

1153378

DUS9
Dual specificity protein phosphatase 9

4

20

High-throughput

0.895

High

1153367

MK14
Mitogen-activated protein kinase 14

2

17

High-throughput

0.806

High

583557

ATF2
Cyclic AMP-dependent transcription factor ATF-2

5

20

Small-scale

0.699

High

272213

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.691

High

290318

KS6A4
Ribosomal protein S6 kinase alpha-4

1

20

High-throughput

0.691

High

923352

MK12
Mitogen-activated protein kinase 12

1

18

High-throughput

0.691

High

1153373

RHG12
Rho GTPase-activating protein 12

1

7

High-throughput

0.691

High

1153379

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

20

High-throughput

0.691

High

603279

KPCA
Protein kinase C alpha type

1

18

High-throughput

0.665

High

650177

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.665

High

896762

DYN2
Dynamin-2

1

3

High-throughput

0.665

High

1096016

TADBP
TAR DNA-binding protein 43

1

13

High-throughput

0.665

High

1096442

PAK1
Serine/threonine-protein kinase PAK 1

1

15

High-throughput

0.665

High

578489

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.653

High

186211

PPM1D
Protein phosphatase 1D

1

13

Small-scale

0.647

High

664752

CCND1
G1/S-specific cyclin-D1

1

20

Small-scale

0.647

High

1153370

NOXA1
NADPH oxidase activator 1

1

2

Small-scale

0.647

High

703943

DUS1
Dual specificity protein phosphatase 1

1

20

Small-scale

0.618

High

1052829

DUSP2
Dual specificity protein phosphatase 2

1

20

High-throughput

0.618

High

1153033

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

13

Small-scale

0.618

High

1153366

PKN1
Serine/threonine-protein kinase N1

1

20

Small-scale

0.618

High

1153383

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

19

Small-scale

0.618

High

1153385

DUS10
Dual specificity protein phosphatase 10

1

20

Small-scale

0.618

High

529863

TAU
Microtubule-associated protein tau

2

19

Small-scale

0.602

High

464969

SP1
Transcription factor Sp1

1

11

Small-scale

0.575

High

1153372

MAPK5
MAP kinase-activated protein kinase 5

1

20

Small-scale

0.575

High

714153

PML
Protein PML

1

12

Small-scale

0.561

High

188287

HDAC3
Histone deacetylase 3

1

8

Small-scale

0.549

High

211644

ZNHI1
Zinc finger HIT domain-containing protein 1

1

2

Small-scale

0.536

High

687809

SYVC
Valine--tRNA ligase

1

8

High-throughput

0.536

High

1134911

CUL7
Cullin-7

1

3

High-throughput

0.536

High

384418

CRYAA
Alpha-crystallin A chain

1

7

High-throughput

0.515

High

966352

1433G
14-3-3 protein gamma

1

20

High-throughput

0.515

High

1123913

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.515

High

1139714

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

High-throughput

0.515

High

1153371

Q86V38
Atrophin 1

1

4

High-throughput

0.515

High

1153374

LMO3
LIM domain only protein 3

1

7

High-throughput

0.515

High

1153376

KLK6
Kallikrein-6

1

2

High-throughput

0.515

High

1153377

KAT5
Histone acetyltransferase KAT5

1

1

High-throughput

0.515

High

155949

SOCS3
Suppressor of cytokine signaling 3

1

11

High-throughput

0.508

High

216699

HTRA2
Serine protease HTRA2, mitochondrial

1

5

Small-scale

0.501

High

258602

SH21A
SH2 domain-containing protein 1A

1

9

Small-scale

0.501

High

388073

MBP
Myelin basic protein

1

10

Small-scale

0.501

High

422160

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.501

High

1153375

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

Small-scale

0.501

High

167606

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.493

High

1153368

SMN
Survival motor neuron protein

1

0

High-throughput

0.493

High

430624

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.486

High

1153381

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.486

High

347720

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

568645

GYS1
Glycogen [starch] synthase, muscle

1

4

Small-scale

0.479

High

767052

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

20

High-throughput

0.479

High

932570

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

20

High-throughput

0.479

High

1144525

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.479

High

1153380

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

1153382

FBW1A
F-box/WD repeat-containing protein 1A

1

14

Small-scale

0.479

High

1153384

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

343529

CPNE6
Copine-6

1

1

High-throughput

0.464

High

407456

K2C1
Keratin, type II cytoskeletal 1

1

4

Small-scale

0.445

High

413907

P53
Cellular tumor antigen p53

1

13

Small-scale

0.445

High

519380

MYB
Transcriptional activator Myb

1

20

Small-scale

0.445

High

838729

MTREX
Exosome RNA helicase MTR4

1

6

Small-scale

0.445

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025