Protein: MK12
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)

Gene: MK12, MAPK12
Organism: Homo sapiens
Interactions: 56
UniProt ID: P53778

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184610

MK13
Mitogen-activated protein kinase 13

4

19

High-throughput

0.903

High

923354

MYLK3
Myosin light chain kinase 3

3

20

High-throughput

0.861

High

923348

SCRIB
Protein scribble homolog

2

12

Small-scale

0.811

High

912493

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

2

20

Small-scale

0.799

High

923353

PKN1
Serine/threonine-protein kinase N1

1

20

Small-scale

0.747

High

923344

SNTA1
Alpha-1-syntrophin

1

12

Small-scale

0.740

High

923368

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.710

High

703512

MK01
Mitogen-activated protein kinase 1

1

18

High-throughput

0.691

High

923345

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

10

High-throughput

0.691

High

923346

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

19

High-throughput

0.691

High

923352

MK11
Mitogen-activated protein kinase 11

1

18

High-throughput

0.691

High

923360

CDKL3
Cyclin-dependent kinase-like 3

1

19

High-throughput

0.691

High

923364

MK15
Mitogen-activated protein kinase 15

1

20

High-throughput

0.691

High

923370

SNRK
SNF-related serine/threonine-protein kinase

1

5

High-throughput

0.691

High

923371

ST32B
Serine/threonine-protein kinase 32B

1

20

High-throughput

0.691

High

923372

NLK
Serine/threonine-protein kinase NLK

1

18

High-throughput

0.691

High

923367

ERBIN
Erbin

1

6

Small-scale

0.681

High

683978

PTN3
Tyrosine-protein phosphatase non-receptor type 3

3

12

Small-scale

0.677

High

923369

PAR11
Protein mono-ADP-ribosyltransferase PARP11

3

6

High-throughput

0.667

High

443279

CDK1
Cyclin-dependent kinase 1

1

19

Small-scale

0.647

High

923347

SNTB1
Beta-1-syntrophin

1

8

High-throughput

0.647

High

708838

PTN4
Tyrosine-protein phosphatase non-receptor type 4

2

8

Small-scale

0.621

High

241183

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

578429

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

923351

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

10

Small-scale

0.618

High

923358

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.618

High

923375

SRPK3
SRSF protein kinase 3

1

18

High-throughput

0.618

High

923343

DLG1
Disks large homolog 1

2

7

Small-scale

0.595

High

923361

MAPK5
MAP kinase-activated protein kinase 5

1

20

Small-scale

0.575

High

923359

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

7

High-throughput

0.573

High

923341

TERF1
Telomeric repeat-binding factor 1

1

18

High-throughput

0.552

High

923342

GTF2I
General transcription factor II-I

1

3

High-throughput

0.541

High

251729

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

17

High-throughput

0.536

High

323253

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.536

High

923350

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.536

High

923365

GCN1
Stalled ribosome sensor GCN1

1

7

High-throughput

0.536

High

721704

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.515

High

783034

CXG1
Gap junction gamma-1 protein

1

2

High-throughput

0.515

High

421774

A4
Amyloid-beta precursor protein

1

8

High-throughput

0.515

High

216648

HTRA2
Serine protease HTRA2, mitochondrial

1

5

Small-scale

0.501

High

388056

MBP
Myelin basic protein

1

9

Small-scale

0.501

High

529406

TAU
Microtubule-associated protein tau

1

18

Small-scale

0.501

High

923349

PGFRL
Platelet-derived growth factor receptor-like protein

1

10

High-throughput

0.494

High

923356

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

5

High-throughput

0.489

High

923373

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

923357

CPZIP
CapZ-interacting protein

1

0

Small-scale

0.480

High

254342

CC14B
Dual specificity protein phosphatase CDC14B

1

20

Small-scale

0.479

High

277613

H2AY
Core histone macro-H2A.1

1

6

Small-scale

0.479

High

588289

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

695016

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

923355

WDR44
WD repeat-containing protein 44

1

6

High-throughput

0.479

High

923362

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

11

Small-scale

0.479

High

923363

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

923366

SNX27
Sorting nexin-27

1

6

High-throughput

0.479

High

923374

CC14A
Dual specificity protein phosphatase CDC14A

1

20

Small-scale

0.479

High

391730

STAT
Statherin

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025