Protein: MAPK3
MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)

Gene: MAPK3, MAPKAPK3
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q16644

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002224 - toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158102

MK14
Mitogen-activated protein kinase 14

17

20

Small-scale

0.988

High

1153369

MK11
Mitogen-activated protein kinase 11

7

20

High-throughput

0.969

High

879724

MAPK2
MAP kinase-activated protein kinase 2

2

17

High-throughput

0.811

High

1160821

PHC2
Polyhomeotic-like protein 2

1

4

Small-scale

0.713

High

231582

PRKY
Putative serine/threonine-protein kinase PRKY

2

12

High-throughput

0.712

High

1160825

SCYL1
N-terminal kinase-like protein

1

5

High-throughput

0.691

High

956313

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.656

High

1006432

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.647

High

58727

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

3

High-throughput

0.618

High

1160818

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

170167

AURKA
Aurora kinase A

1

15

High-throughput

0.590

High

224124

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

18

High-throughput

0.590

High

363345

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.590

High

373954

RASN
GTPase NRas

1

4

High-throughput

0.590

High

557327

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

High-throughput

0.590

High

578494

BRAF
Serine/threonine-protein kinase B-raf

1

8

High-throughput

0.590

High

845975

DCC
Netrin receptor DCC

1

1

High-throughput

0.590

High

1154367

STK11
Serine/threonine-protein kinase STK11

1

12

High-throughput

0.590

High

415601

HSPB1
Heat shock protein beta-1

2

10

Small-scale

0.585

High

466278

RHOC
Rho-related GTP-binding protein RhoC

1

2

High-throughput

0.575

High

215824

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

1

Small-scale

0.552

High

587481

TFE2
Transcription factor E2-alpha

1

1

Small-scale

0.549

High

1142782

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.546

High

342890

HERC2
E3 ubiquitin-protein ligase HERC2

1

6

High-throughput

0.536

High

1034684

MEF2A
Myocyte-specific enhancer factor 2A

1

1

High-throughput

0.536

High

1160824

LRC46
Leucine-rich repeat-containing protein 46

1

4

High-throughput

0.514

High

1160816

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.513

High

939190

SUMO3
Small ubiquitin-related modifier 3

1

4

High-throughput

0.508

High

1155417

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.508

High

422186

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

617098

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

9

Small-scale

0.501

High

861629

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

High-throughput

0.501

High

1126696

BECN1
Beclin-1

1

1

Small-scale

0.501

High

1160817

CPZIP
CapZ-interacting protein

1

1

Small-scale

0.501

High

1160826

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

5

High-throughput

0.501

High

914052

SPSY
Spermine synthase

1

0

High-throughput

0.486

High

1160819

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.486

High

695583

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

765561

BMI1
Polycomb complex protein BMI-1

1

5

Small-scale

0.479

High

767055

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

4

High-throughput

0.479

High

932572

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

7

High-throughput

0.479

High

1144527

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

5

High-throughput

0.479

High

1160820

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.479

High

1160828

RING2
E3 ubiquitin-protein ligase RING2

1

4

Small-scale

0.479

High

556116

CADH1
Cadherin-1

1

1

High-throughput

0.457

High

1160823

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.457

High

1160827

RHG07
Rho GTPase-activating protein 7

1

4

High-throughput

0.457

High

896386

ERF
ETS domain-containing transcription factor ERF

1

2

High-throughput

0.445

High

1160815

TPD53
Tumor protein D53

1

1

High-throughput

0.445

High

442732

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.438

High

1160822

ARF
Tumor suppressor ARF

1

0

High-throughput

0.438

High

379519

IGHM
Immunoglobulin heavy constant mu

1

2

High-throughput

0.417

High

1144242

PGFRL
Platelet-derived growth factor receptor-like protein

1

3

High-throughput

0.417

High

1160829

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025